万古霉素复合型抗菌药物骨水泥植入术疗法对骨科术后感染的疗效

Effect of vancomycin complex antibiotic cement implantation in the treatment of postoperative infection in orthopedics

目的研究万古霉素复合型抗菌药物骨水泥植入术疗法对导致骨科术后感染的疗效。方法选取2014年2月至2016年2月于本院接受治疗的骨科感染者429例,计算机随机系统将患者随机分为试验组(215例行万古霉素复合抗菌药物骨水泥植入术患者)和对照组(214例行CEMEX GEN抗菌药物骨水泥植入术患者),依据随访观察指标与治愈标准汇总试验结果,并采用统计学方法进行分析对比。结果传统的彻底清创外加万古霉素复合型抗菌药物骨水泥植入术疗法对治疗骨科感染较单一型抗菌药物骨水泥植入术(含庆大霉素的抗菌药物)疗效更好,治愈率高达89.77%,而单一型抗菌药物骨水泥植入术(含庆大霉素)的治愈率仅为37.85%,两者差异有统计学意义(χ~2=12.363、P=0.024),两种治疗方法的术后并发症发生率差异无统计学意义(χ~2=5.710、P=0.074)。结论万古霉素复合型抗菌药物骨水泥植入术疗法对治疗骨科感染疗效远优于单一型抗菌药物骨水泥植入术疗法。

Objective To investigate the efficacy of vancomycin combined with antibiotic bone cement implantation in the treatment of common infections in orthopedics. Methods From February 2014 to February 2016, total of 429 patients with orthopedics infection in our hospital were divided into experimental group（215 cases with vancomycin combined antibiotic bone cement implantation surgery） and the control group（214 cases with CEMEX GEN antibiotic bone cement implantation surgery） randomly. The experimental results were collected according to the follow up indexes and cure standard, which were analyzed by statistical methods. Results The curative effect of traditional debridement plus vancomycin composite antibiotic bone cement implantation therapy to treat orthopedics infection was better compared with single type antibiotic bone cement implantation（using gentamicin antibiotic）, the cure rate of the former was 89.77%, while the cure rate of the latter was only 37.85%, with significant difference（χ^2 = 12.363, P = 0.024）, but the postoperative complications of two treatment methods were without significant difference（χ^2 = 5.710, P = 0.074）. Conclusions The curative effect of vancomycin combined with antibiotic bone cement implantation to treat orthopedics infection was much better than that of single antibiotic bone cement implantation.