抑郁症神经内分泌免疫炎症的研究进展

Research progress of neuroendocrine immune inflammation in depression

抑郁症是由多种因素引起的情绪障碍,发病机制复杂,且发病率逐年增高。目前研究认为,抑郁症的发生涉及神经内分泌和细胞免疫炎症的变化,抑郁症患者促炎物质改变,免疫活化物增加,进而影响大脑的结构与功能,但其具体机制有待进一步研究。本研究主要讨论神经内分泌及细胞免疫炎症与抑郁症的相关性。

Depression is a mood disorder caused by many factors.The pathogenesis is complex,and the incidence is increasing year by year.Recent studies have suggested that the occurrence of depression involves changes in neuroendocrine and cytoimmune inflammation.In patients with depression,proinflammatory substances change,immune activation substances increase affect the structure and function of brain.Its specific mechanism remains to be further studied.In this review,the correlation between neuroendocrine and cytoimmune inflammation and depression is reviewed.