IVF与ICSI子代足月双胎婴儿体格生长及发育商比较

Comparison of infancy physical growth and developmental quotient of full-term twins between in-vitro fertilization and intracytoplasmic sperm injection

目的:探讨体外受精—胚胎移植(in-vitro fertilization,IVF)与卵胞浆内单精子注射(intracytoplasmic sperm injection,ICSI)技术辅助生殖的子代足月双胎婴儿的体格生长及发育商的差异。方法:随机选取2015~2017年在兰州大学第一医院生殖中心通过IVF或ICSI辅助生殖的足月双胎儿90例,按辅助生殖技术分为IVF组(n=50)和ICSI组(n=40)。并选取50例同期自然受孕(natural conception,NC)的足月双胎儿为NC组,比较3组在出生时、6月龄、12月龄的身长、体质量、头围,并使用格塞尔婴幼儿发展量表(gesell developmental schedules,GESELL)评估6月龄和12月龄的发育商。结果:IVF组与ICSI组在出生时和婴儿期的身长、体质量、头围无明显差异,且与NC组接近(P>0.05)。6月龄时IVF组、ICSI组语言能力评分均低于NC组(P<0.05);3组间大运动、精细运动、适应能力、个人-社会能力评分无统计学差异。12月龄时,3组间GESELL所有指标评分比较差异均无统计学意义(P>0.05)。结论:IVF和ICSI两种辅助生殖子代足月双胎儿婴儿期的发育水平均在正常范围,与自然受孕足月双胎婴儿发育水平相仿。

Objective：To investigate the difference of physique gronth and developmental quotient of full-term twins between in-vitro fertilization（IVF）and intracytoplasmic sperm injection（ICSI）.Methods：Ninety cases full-term twins who was born with assisted reproductive technology（ART）from 2015 to 2017 in the first hospital of Lanzhou university were divided into IVF group（n=50）and ICSI group（n=40）,and 50 cases were selected as natural conception（NC）group.The physique growth and developmental quotient in three group were compared.Results：There were no significant differences between IVF group and ICSI group on the length、weight and head circumference when they were born and in infancy（P〉0.05）.At the age of 6 months,the language competences in IVF group and ICSI group was lower than that in NC group（P〈0.05）.Gross motor,fine motor,adaptability and personalsocial skill score at the age of 6 months and all GESELL score had no significant differences between the three groups（P〉0.05）.Conclusion：There are no significant differences between IVF and ICSI full-term twins on physique growth and developmental quotient in infancy,which is similar to that of the natural conceived term born twins in infant.