儿童喘息性疾病中RSV与MP联合检测的意义及其与哮喘的关系

Combined Detection of Respiratory Syncytial Virus and Mycoplasma Pneumoniae and Relationship with Asthma in Children

目的:探讨呼吸道合胞病毒(RSV)与肺炎支原体(MP)联合检测在儿童喘息性疾病诊断中的意义及其与哮喘的关系。方法:选取2012年1月至2014年12月我院收治的急性呼吸道感染患儿680例,根据有无喘息症状、肺部哮鸣音分为喘息组和无喘息组,其中喘息组362例,无喘息组318例,两组患儿均联合检测RSV与MP。结果:680例患儿中单一病原体阳性共221例,其中RSV阳性检出率为18.24%,MP阳性检出率为14.26%,RSV合并MP阳性检出率为2.79%。喘息组RSV、MP阳性检出率以及家族史、特应性体质发生率均明显高于无喘息组(P<0.05)。喘息组获得预防干预患儿哮喘发病率明显低于未干预患儿(P<0.05)。结论:RSV与MP联合检测有助于筛查喘息性疾病患儿的病原菌,提高临床诊断效果,实现对症治疗,同时对患儿哮喘的预防也具有重要的参考意义。

Objective： To investigate the significance of combined detection of respiratory syncytial virus（RSV） and Mycoplasma pneumoniae（ MP） and relationship with asthma in children. Methods： Six hundreds and eighty children with respiratory tract infection from Jan. 2012 to Dec. 2014 in our hospital were divided into wheezing group（ n = 362） and no wheezing group（ n = 318）,and both groups were detected with RSV and MP. Results： Among the 680 cases,221 cases were positive for single pathogens,and the RSV positive detection rate was 18.24%,while the MP positive detection rate was 14.26%,and the positive detection rate of RSV and MP was 2.79%. The positive detection rate of RSV and MP and the incidence rate of family history and atopic constitution in wheezing group were significantly higher than those in no wheezing group（ P〈0.05）. The incidence of asthma in children with preventive intervention in the wheezing group was significantly lower than the children without preventive intervention（ P〈0.05）. Conclusion： The combined detection of RSV and MP is helpful for screening pathogens of asthma in children,improving the efficiency of clinical tests,and achieving symptomatic treatment,which also has important reference significance for the prevention of asthma.