射频消融和手术切除在原发性小肝癌患者中的安全性和有效性研究

A Study on Safety and Efficacy of Radiofrequency Ablation and Surgical Resection in Treatment of Patients with Primary Small Hepatocellular Carcinoma

目的比较射频消融和手术切除在原发性小肝癌患者中的安全性和有效性。方法选取2015年1月—2016年6月自贡市第四人民医院收治的原发性小肝癌120例,按照治疗方法分为观察组和对照组,每组60例。观察组给予射频消融治疗,对照组给予手术切除,观察2组近远期效果。结果观察组住院时间短于对照组(P<0.05);观察组术后1、6月时健康相关的生存质量(SF-36)高于对照组(P<0.05)。观察组总不良反应发生率低于对照组(P<0.05)。2组术后1年时疗效比较差异无统计学意义(P<0.05)。2组术后12、24、36个月时复发率、病死率比较差异均无统计学意义(P>0.05)。结论射频消融可显著改善原发性小肝癌患者近期生活质量,不增加其术后复发率。

Objective To compare safety and efficacy between radioffequency ablation and surgical resection in treatment of patients with primary small hepatocellular carcinoma. Methods A total of 120 patients with prilnary small hepatocellular carcinoma during January 2015 and June 2016 were divided into observation group （n 60） and control group （n =60） according to therapeutic methods. Observation group was treated with radioffequency ablation, while control group was treated with surgery. The short-terln and long-terln effects were observed in two groups. Results Coin- pared with those in control group, in observation group, hospitalization time was shorter （P 〈0.05） , and the health re- lated quality of life （SF-36） scores in 1 month and 6 months after surgery were significantly higher （P 〈 0.05） , and total incidence rate of adverse reactions in obsetwation group was significantly lower （P 〈 0. 05）. There was no significant difference in effect between two groups in 1 year after surgery （P 〈0.05）. There was no significant difference in effect between two groups （P 〉 0.05）. Conclusion Radioffequency ablation lnay significantly improve short-terln quality of life in patients with prilnm3J SlnM1 hepatocellular carcinoma without increasing postoperative recurrence rate.