上皮性卵巢癌患者血清CA125、HE4、CEA水平表达及临床意义

Expressions and Clinical Significances of Serum CA125,HE4 and CEA in Patients with Epithelial Ovarian Cancer

目的探讨糖类抗原(CA125)、人附睾蛋白4(HE4)、癌胚抗原(CEA)在上皮性卵巢癌血清中的表达及临床意义。方法选取2013年1—12月新疆医科大学第二附属医院妇产科收治的上皮性卵巢癌50例、良性卵巢肿瘤45例及同期健康体检者45例为研究对象,检测并比较3组血清中CA125、HE4、CEA表达水平,并分析其与上皮性卵巢癌病理特征及预后的关系。结果上皮性卵巢癌组血清CA125、HE4、CEA水平高于健康体检组和卵巢良性肿瘤组(P<0.05),且血清CA125与HE4水平呈明显正相关(r=0.557,P<0.05)。上皮性卵巢癌组血清CA125水平与临床分期、淋巴结转移明显相关(P<0.05),HE4与临床分期、组织分化、淋巴结转移及腹水产生明显相关(P<0.05),而CEA仅与临床分期相关(P<0.05);不同预后患者血清CA125、HE4、CEA水平比较差异均有统计学意义(P<0.05)。结论上皮性卵巢癌患者血清CA125、HE4、CEA水平均与疾病进展相关,且各指标高表达均提示预后不良。

Objective To investigate expressions and clinical significances of carbohydrate antigen125 （CA125） , human epididymal protein 4 （HE4） and carcinoembryonic antigen （CEA） in serum of patients with epithelial ovarian cancer. Methods A total of 50 patients with epithelial ovarian cancer, 45 patients with benign ovarian neoplasms and 45 healthy people taking physical examination from January to December 2013 were recruited in this study. Serum CA125, HFA and CEA levels were detected and compared among three groups, and then correlations with clinico- pathological features and prognosis of patients were analyzed. Results Serum CA125, HE4 and CEA levels in epithelial ovarian cancer group were significantly higher than those in healthy exalnination and benign ovarian neoplasms groups （P〈0. 05）,andtherewasapositivecorrelationbetweenserum CA125 and HFA（r =0.557, P〈0.05）. Serum CA125 level was significantly correlated with clinical stage and lymph node metastasis in patients with epithelial ovarian cancer （P 〈 0. 05）, and HE4 level was significantly correlated with clinical stage, histodifferentiation, lymph node metastasis and ascites （P 〈 0.05） , while CEA level was only correlated with clinical stage in epithelial ovarian cancer tissues （P 〈 0.05）. Serum CA125, HFA and CEA levels in patients with different prognosis showed significant differences （P 〈 0.05）. Conclusion Serum CA125, HE4 and CEA levels in patients with epithelial ovarian cancer are closely related to progression of the disease, and high expressed each index can indicate poor prognosis.