老年颈动脉粥样硬化患者斑块稳定性与血浆D-二聚体和血小板计数水平的关系

Relationships between Plaque Stability with Plasma D-dimer and Platelet Count in Elderly Patients with Carotid Atherosclerosis

目的探讨老年颈动脉粥样硬化患者斑块稳定性与血浆D-二聚体(D-D)、血小板计数(PLT)的关系。方法抽取中国石油天然气集团公司中心医院2017年1月—2018年1月就诊的老年颈动脉粥样硬化100例为观察组,并根据斑块形成与否及稳定性分为斑块形成和斑块未形成,稳定性斑块和不稳定性斑块;同时选取同期健康体检者60例为对照组,比较2组间血浆D-D水平、PLT,并分析其与颈动脉斑块稳定性的相关性。结果观察组血浆D-D水平高于对照组、PLT计数低于对照组(P<0.05);斑块形成者血浆D-D水平高于斑块未形成者、PLT低于斑块未形成者(P<0.05),稳定斑块者血浆D-D低于不稳定斑块者、PLT高于不稳定斑块者(P<0.05);稳定斑块者与血浆D-D水平、PLT呈负相关(P<0.05);不稳定斑块者与血浆D-D正相关(P<0.05),与PLT无显著相关(P>0.05)。结论老年颈动脉粥样硬化患者血浆D-D水平升高,PLT下降,二者与颈动脉硬化斑块形成具有相关性。

Objective To investigate relationships between plaque stability with plasma D-dimer （D-D） and platelet count （PLT） in elderly patients with carotid atheroselerosis. Methods A total of 100 elderly patients with carotid atheroselerosis admitted during January 2017 and January7 2018 were selected as observation group, and were divided into plaque formation subgroup, non plaque formation subgroup, stable plaque subgroup and unstable plaque subgroup ac- cording to whether or not having plaque formation and plaque stability, and then other 60 healthy people taking physical examination during the same period were selected as control group. Plasma D-D and PLT levels were compared between two groups, and relationships between D-D and PLT with carotid plaque stability were analyzed. Results In observation group, plasma D-D level was higher, while PLT value was lower than those in control group （P （0.05）. In plaque formation subgroup, plasma D-D level was higher, while PLT value was lower than those in non-plaque formation subgroup （P （0.05）. In stable plaque subgroup, plasma D-D level was lower, while PLT value was higher than those in unstable plaque subgroup （P 〈0.05）. Stable plaque was negatively correlated with plasma D-D level and PLT value in stable plaque subgroup （P 〈0.05） , while it was positively correlated with plasma D-D level （P 〈0.05） , but it was no signifi- cant correlation with PLT in unstable plaque subgroup （P 〉 0.05）. Conclusion Increased plasma D-D level and de- creased PLT value can be found in elderly patients with carotid atheroselerosis, and they are correlated with forination of carotid atheroselerotie plaques.