对比分析采用动脉瘤介入栓塞术与颅内动脉瘤夹闭术治疗高分级动脉瘤性蛛网膜下腔出血的效果

Comparative Analysis of Aneurysmal Interventional Embolization and Intracranial Aneurysm Clipping for the Treatment of High Grade Aneurysmal Subarachnoid Hemorrhage

目的研究高分级动脉瘤性蛛网膜下腔出血接受动脉瘤介入栓塞术与颅内动脉瘤夹闭术治疗的临床效果。方法选择2015年1月—2017年6月该院高分级动脉瘤性蛛网膜下腔出血患者80例,依据治疗方法的不同将全部患者进行分组,观察组40例接受动脉瘤介入栓塞术治疗,对照组40例接受颅内动脉瘤夹闭术治疗,比较两组临床治疗效果。结果观察组治疗总有效率为87.5%,并发症发生率为7.5%,对照组57.5%、27.5%,差异有统计学意义(χ~2=8.542 9,5.541 1,P<0.05);观察组术后3 d IgG、IgA、IgM分别为(10.02±4.99)、(2.12±0.48)、(1.24±0.60)g/L,对照组术后3 d分别为(8.99±3.66)、(1.64±0.53)、(0.93±0.24)g/L,差异有统计学意义(t=5.894 7,6.201 5,4.021 9,P<0.05)。结论动脉瘤介入栓塞术治疗高分级动脉瘤性蛛网膜下腔出血的效果要优于颅内动脉瘤夹闭术,能够降低并发症发生率,同时不会明显影响患者免疫状态,值得广泛推广。

Objective This paper tries to study the clinical effects of interventional embolization and intracranial aneurysm clipping in patients with high grade aneurysmal subarachnoid hemorrhage. Methods 80 patients with high grade aneurysmal subarachnoid hemorrhage in this hospital from January 2015 to June 2017 were selected. All patients were grouped according to different treatment methods. 40 patients in the observation group received interventional embolization for aneurysm. 40 patients in the control group received intracranial aneurysm clipping surgery, and the clinical effects of the two groups were compared. Results The total effective rate in the observation group was 87.5%, the complication rate was 7.5%, and the control group was 57.5% and 27.5%, the difference was statitiscally significant（χ^2=8.542 9,5.541 1,P〈0.05）. The IgG, IgA, and IgM in the observation group at the 3 d after the operation were（10.02±4.99）,（2.12±0.48）,（1.24±0.60）g/L, and the control group was（8.99±3.66）,（1.64±0.53）,（0.93±0.24）g/L, respectively, the difference was statistically significant（t=5.894 7, 6.201 5, 4.021 9, P〈0.05）. Conclusion Aneurysm intervention embolization is superior to intracranial aneurysm surgery in the treatment of high-grade aneurysmal subarachnoid hemorrhage, which can reduce the incidence of complications, and it will not significantly affect the immune status of patients, and it is worthy of widespread promotion.