老年H型高血压患者同型半胱氨酸与ApoB/ApoA1相关性

Correlation between Hcy and ApoB/ApoA1 in elderly patients with H-type hypertension

目的探讨老年H型高血压患者血浆同型半胱氨酸(Hcy)与血清载脂蛋白B/载脂蛋白A1的相关性。方法随机选取2015年1月至2018年4月合肥市第三人民医院老年病科老年高血压患者204例。根据Hcy值将患者分成两组,设H型高血压组(Hcy≥10μmol/L)为A组(144例);非H型高血压组(Hcy<10μmol/L)为B组(60例)。监测血清载脂蛋白B(ApoB)、载脂蛋白A1(Apo A1)水平,并计算ApoB/Apo A1比值,同时收集两组患者的血压、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白胆固醇(VLDL-C)、高密度脂蛋白胆固醇(HDL-C)、尿酸(UA)、空腹血糖(FPG)、肌酐(CREA)、尿素氮(GREA)等临床资料。比较两组患者的临床资料及ApoB/Apo A1比值。采用Pearson相关分析高Hcy与多种因素的相关性,采用二元logistic回归分析H型高血压患病的影响因素。结果 A组患者的男性比例、年龄、高血压病程、Hcy、ApoB、ApoB/Apo A1比值、UA、CREA均高于B组,差异均有统计学意义(P<0.01)。老年H型高血压Hcy与ApoB/Apo A1比值、UA、CREA呈正相关(r=0.234、0.250、0.223,P<0.05)。logistic回归分析显示:ApoB/Apo A1是老年H型高血压的危险因素(OR=43.822,P<0.001)。结论老年H型高血压Hcy与ApoB/Apo A1比值呈正相关,ApoB/Apo A1是老年H型高血压的危险因素。

Aim To investigate the relationship between Hey and serum apolipoprotein B/ apolipoprotein A1 in elderly patients with H -type hypertension. Methods A total of 204 elderly patients with H - type hypertension treated in the Third Peopley s Hospital of Hefei hospital from 2016 to 2018 were selected and divided into two groups, namely, H - type hypertension group （〈 10μmol/L） as group A （n =144） and the non - H - type hypertension group （ 〈 10μmol/L） as group B （ra = 60 ） , according to the values measured in plasma homo-cysteine. Serum apolipoprotein B （ ApoB） , apolipoprotein A1 （ ApoAl） levels were monitored, the ratio was calculated, and the two groups＊ blood pressure, triacylglycerol （TG） , total cholesterol （TC） , low - density lipoprotein cholesterol （LDL-C） , very low density lipoprotein cholesterol （ VLDL - C） , high - density lipoprotein cholesterol （ HDL - C） , uric acid （ UA） , fasting plasma glucose （ FPG） , creatinine （CREA） , urea nitrogen （ GREA） were collected at the same time. The differences between the two groups in clinical data and ApoB/ApoAl ratio were compared. Pearson linear analysis was used to analyze the correlation between high Hey and various factors, and binary Logistic re-gression was used to analyze the influencing factors of h - type hypertension. Results The male ratio, age,hypertension course, Hey, ApoB, ApoB/ApoAl ratio, UA and CREA of group A were all higher than those of group B, with statistically significant difference （P 〈 0.01）. There was a positive correlation between Hey and ApoB/ApoAl ratio, UA and CREA （r =0.234, 0.250, 0.223, P 〈 0.05）. Lo-gistic regression analysis showed that ApoB/ApoAl was a risk factor for type H hypertension in the elderly （OR = 43. 822, P 〈0. 001）. Conclusion There is a correlation between Hey and ApoB/ApoAl.