亚甲基四氢叶酸还原酶基因C667T多态性与EH相关性分析

A correlation analysis between C667T polymorphism of MTHFR and prevalence risk of EH: a Meta-analysis

目的:探讨亚甲基四氢叶酸还原酶(MTFHR)基因C667T位点的多态性与原发性高血压(EH)患病风险的相关性。方法:利用计算机检索Pub Med、EMbase和Web of Science数据库、CNKI、万方数据库和维普中文科技期刊全文数据库中有关MTHFR基因C677T多态性与EH相关性的研究文献,检索时限均为各数据库建库至2017年12月。由两名研究人员同时进行文献筛选及资料提取,应用Stata13.1软件对符合纳入及排除标准的研究进行Meta分析。结果:共纳入文献43篇,包括8411例EH患者,8337例对照者。经Meta分析,MTHFR基因C667T多态性与EH发病风险的相关性在等位基因模型[T与C比较:OR 95%置信区间(95%CI)为1.18~1.39)]、纯合子模型(TT与CC比较:95%CI为1.36~1.94)、杂合子模型(CT与CC比较:95%CI为1.16~1.39)、显性遗传模型(TT+CT与CC比较:95%CI为1.23~1.51)和隐性遗传模型(TT与CC+CT比较:95%CI为1.23~1.61)中均有统计学意义(OR=1.28,OR=1.63,OR=1.27,OR=1.36,OR=1.41;P<0.05),尤其是在亚洲人群中MTHFR基因C677T位点多态性与EH的发病风险有相关性,美洲人群、大洋洲人群的MTHFR基因C677T位点多态性则与EH的发病风险无相关性。结论:MFTHR基因C667T位点多态性与EH发病风险有显著的相关性。

Objective： To investigate the correlation between C677 T polymorphism of methylenetetrahydrofolate reductase（MTHFR） and prevalence risk of essential hypertension（EH）in different population. Methods： Series of database included Pub Med, EMbase, Web of Science, CNKI, Wan Fang Database and VIP were searched by using computer to find the case-control studies about the correlation between C677 T polymorphism of MTHFR and prevalence risk of EH from the time of databases＇ establishing to December, 2017. Two reviewers independently screened the title, abstract and keywords of each article. Meta-analysis of the studies which met the inclusion and exclusion criteria was performed by using STATA13.1 software. Results： 43 case-control studies with 8411 patients of EH and 8337 controlled cases were included in this research. C677 T polymorphism of MTHFR is significantly associated with EH in allele model（T vs C： OR=1.28, 95%CI： 1.18-1.39）, homozygote model（TT vs CC： OR=1.63, 95%CI： 1.36-1.94）, heterozygous model（CT vs CC： OR=1.27, 95%CI： 1.16-1.39）, dominant genetic model（TT＋CT vs CC： OR=1.36, 95%CI： 1.23-1.51） and recessive genetic model（TT vs CC＋CT： OR=1.41, 95%CI： 1.23-1.61）, especially in Asian. It was not correlation between the prevalence risk of EH and C677 T polymorphism of MTHFR in populations of American and Oceania. Conclusion： The results show that C677 T polymorphism of MTHFR is correlated with prevalence risk of EH.