肝动脉给药研究进展

Development of hepatic arterial administration

肝动脉给药是指在辅助手段引导下,经导管将药物或栓塞剂注入肝动脉的一种区域性给药方法。该方法具有有效、安全、定位准确、患者顺应性高、可多种技术联合应用等优点,已成功用于原发性肝细胞癌、肝内胆管细胞癌、肝脓肿等疾病的治疗,并取得良好的治疗效果。但该技术在并发症、栓塞剂选择、药物吸收等方面仍有不足。本文就肝动脉给药的技术方法、应用进展、存在的问题进行综述。

Hepatic arterial administration refers to a regional delivery of drugs or embolization agents into the hepatic artery under the guidance of auxiliary means. The method is effective and safe with the advantages of accurate positioning and high patient＇s compliance, which can be combined with multiple technologies. The method has been successfully used in the treatment of hepatocellular carcinoma （HCC） , intrahepatic cholangiocarcinoma （ ICC ） , pyogenic liver abscess （PLA）. However, the technology still has deficiencies in complications, embolic agent selection, drug absorption and so on. In this paper, technical methods, application progress and existing problems of hepatic artery administration were reviewed.