抗线粒体抗体-M2阳性体检人群患原发性胆汁性肝硬化相关指标调查分析

Investigation on Primary Biliary Cirrhosis Related Indicators in Anti-mitochondrial Antibody-M2 Positive Physical Examination Group

目的了解体检人群中原发性胆汁性肝硬化(PBC)患病率及潜在患病风险。方法通过检测2015年1—12月9 137名体检者自身抗体AMA-M2,分析PBC的患病率、患病特点。结果在9 137名普通健康体检者中,检出AMA-M2阳性有209例,这209例如中有10例诊断为PBC,患病率是109.44/10~5,男性患病率低于女性。确诊10例PBC患者中AMA-M2>800 RU/mL;2例600 RU/mL<AMA-M2<800 RU/mL,1例合并脂肪肝,1例合并高甘油三酯血症,其余均为25 RU/mL<AMA-M2<100 RU/mL均合并脂肪肝、慢性胆囊炎、胆结石、饮酒史等。结论检测AMA-M2抗体对于PBC疾病早期发现、早期干预意义重大。对于PBC的关注和AMA-M2检测,将对患者本人及社会减轻经济负担。

Objective To know the morbidity and potential prevalence risk of primary biliary cirrhosis related indicators in anti-mitochondrial antibody-M2 positive physical examination group. Methods The autoantibody AMA-M2 of 9 137 cases of physical examination people from January to December 2015 was tested thus analyzing the morbidity and disease features of PBC. Results Of 9 137 cases of common healthy physical examination people, there were 209 cases with positive AMA-M2, and 10 cases were diagnosed with PBC, and the morbidity was 109.44/10~5, and the morbidity in males was lower than that in females, and AMA-M2 800 RU/mL in 10 cases, 600 RU/mL AMA-M2 800 RU/mL in 2 cases, 1 case with hepatic adipose infiltration, 1 case with hypertriglyceridemia, and the other was 25 RU/mL AMA-M2 100 RU/mL, with hepatic adipose infiltration, chronic cholecystitis, gallstones, drinking history. Conclusion Testing the AMA-M2 antibody is of great significance to the early discovery and early intervention of PBC, and the attention of PBC and testing of AMA-M2 can relieve the economic burden to the patients and society.