右美托咪定复合不同剂量舒芬太尼对脊柱手术患者术后镇痛的影响

Effect of Dexmedetomidine Combined with Different Doses of Sufentanil on the Postoperative Analgesia of Patients with Spine Surgery

目的探讨右美托咪定复合不同剂量舒芬太尼对脊柱手术患者术后镇痛的影响。方法研究对象共有57例,为该院2016年11月—2017年12月所接收的在该院接受骨科手术治疗的患者,分组采用数字表分组法,将所选取的研究对象分为3组,即对照组、观察1组和观察2组。给予对照组患者单纯2μg/kg舒芬太尼药物进行术后镇痛,给予观察1组患者1.5μg/kg右美托咪定药物复合2μg/kg舒芬太尼药物进行术后镇痛,给予观察2组患者接受的镇痛方法为1.5μg/kg右美托咪定复合1.5μg/kg舒芬太尼药物进行术后镇痛。观察并对比右美托咪定药物复合两种不同剂量的舒芬太尼以及单纯使用舒芬太尼在脊柱手术患者术后镇痛工作中所能发挥的临床应用效果。结果对照组患者T_1、T_2、T_3、T_4VAS评分分别为(2.60±0.75)分、(3.10±0.71)分、(3.10±0.68)分、(3.20±0.60)分;观察1组分别为(1.85±0.67)分、(2.30±0.57)分、(2.20±0.41)分、(2.40±0.31)分,观察2组分别为(1.97±0.51)分、(2.63±0.76)分、(2.68±0.63)分、(2.76±0.25)分,经过该次研究发现,观察1组、观察2组与对照组患者在接受术后镇痛之后,对患者进行术后VAS评分,观察1组、观察2组与对照组之间差异有统计学意义(t=5.491、4.393、8.654、4.506,4.467、7.361、3.689、8.451,P<0.05)。结论在脊柱手术患者的术后镇痛工作当中,将右美托咪定药物运用在其中可以减少舒芬太尼药物的使用剂量,进而减少不良反应的发生几率,加快患者术后的恢复。

Objective To study the effect of dexmedetomidine combined with different doses of sufentanil on the postoperative analgesia of patients with spine surgery. Methods 57 cases of patients with orthopedic surgery in our hospital from November 2016 to December 2017 were selected and randomly divided into three groups, the control group used the simple 2 μg/kg sufentanil drugs for postoperative analgesia, while the observation 1 group used the 1.5 μg/kg dexmedetomidine combined with 2 μg/kg sufentanil drugs, while the observation 2 group used the 1.5 μg/kg dexmedetomidine combined with 1.5 μg/kg sufentanil drugs, and the clinical application effect of the combination and the single drug was compared. Results The VAS scores at T1, T2, T3, T4 in the control group, in the observation 1 group and in the observation 2 group were respectively（2.60±0.75）points,（3.10±0.71）points,（3.10±0.68）points,（3.20±0.60）points;（1.85 ±0.67）points,（2.30 ±0.57）points,（2.20 ±0.41）points,（2.40 ±0.31）points;（1.97 ±0.51）points,（2.63 ±0.76）points,（2.68±0.63）分,（2.76±0.25）分, and the research showed that the differences in the VAS scores between the observation 1 group, observation 2 group and the control group were obvious, namely（t =5.491, 4.393, 8.654,4.506,4.467,7.361,3.689,8.451,P 0.05）. Conclusion The application of dexmedetomidine drugs in the postoperative analgesia of patients with spine surgery can reduce the use dosage of sufentanil drugs thus reducing the occurrence probability of adverse reactions and accelerating the postoperative recovery.