鳖甲煎丸对慢性乙肝合并肝硬化患者炎症因子及肝纤维化指标的影响

Effect of Biejia Jian Pill on inflammatory factors and liver fibrosis indexes in patients with chronic hepatitis B complicated with cirrhosis

目的:探讨鳖甲煎丸对慢性乙肝合并肝硬化患者炎症因子及肝纤维化指标的影响。方法:选取2017年1～12月我院收治的94例慢性乙肝合并肝硬化患者纳入本研究,随机分为观察组47例与对照组47例,对照组给予阿德福韦酯片,观察组在对照组的基础上联合使用鳖甲煎丸,比较两组治疗前后肝功能、炎症因子及肝纤维化指标的变化。结果:治疗前,两组患者的谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBIL)、血清白蛋白(ALB)均无统计学差异(P>0.05);治疗后,两组患者的AST、ALT、TBIL均降低,且观察组的AST、ALT、TBIL低于对照组,两组患者的ALB均升高,且观察组的ALB高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组患者的肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-10(IL-10)均无统计学差异(P>0.05);治疗后,两组患者的TNF-α、IL-1β均降低,且观察组的TNF-α、IL-1β低于对照组,两组患者的IL-10均升高,且观察组的IL-10高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组患者的透明质酸(HA)、层黏连蛋白(LN)、Ⅳ型胶原(Ⅳ-C)、Ⅲ型前胶原(PCⅢ)均无统计学差异(P>0.05);治疗后,两组患者的HA、LN、IV-C、PCⅢ均降低,且观察组的HA、LN、IV-C、PCⅢ低于对照组,差异均有统计学意义(P<0.05)。结论:鳖甲煎丸能够有效改善慢性乙肝合并肝硬化患者的炎症因子及肝纤维化程度。

Objective：To detect the effect of BieJia Jian Pill on inflammatory factors and liver fibrosis indexes in patients with chronic hepatitis B complicated with cirrhosis.Methods：A total of 94 patients with chronic hepatitis B combined with cirrhosis in our hospital from January 2017 to December 2017 were selected as the subjects,and they were randomly divided into observation group and control group,with 47 cases in each group.The control group was given Adefovir Dipivoxil Tablets,and the observation group was treated with Bijia Jian pills on the basis of the control group.The changes of liver function,inflammatory factors and liver fibrosis indexes were compared between the two groups before and after treatment.Results：Before treatment,there was no significant difference in AST,ALT,TBIL and ALB between the two groups（P〈0.05）.After treatment,the AST,ALT and TBIL of the two groups were all decreased,and the AST,ALT and TBIL in the observation group were lower than those of the control group;the ALB of the two groups was increased,and the ALB of the observation group was higher than that of the control group（P〈0.05）.Before treatment,there was no significant difference in TNF-α,IL-1βand IL-10 between the two groups（P〈0.05）.After treatment,the TNF-αand IL-1βof the two groups were decreased,and the TNF-αand IL-1βin the observation group were lower than those of the control group;the IL-10 of the two groups increased,and the IL-10 in the observation group was higher than that in the control group（P〈0.05）.Before treatment,there was no significant difference in HA,LN,IV-C and PCⅢ between the two groups（P〈0.05）.After treatment,the HA,LN,Ⅳ-C and PCⅢ of the two groups were all decreased,and the HA,LN,Ⅳ-C and PCⅢ of the observation group were lower than those of the control group（P〈0.05）.Conclusion：BieJia Jian pills can effectively improve the inflammatory factors and liver fibrosis in patients with chronic hepatitis B complicated with cirrhosis.