抗血小板药物联合硫酸镁对子痫前期患者血小板功能及滋养细胞凋亡侵袭的影响

Effects of antiplatelet drug combined with magnesium sulfate on platelet function and trophoblast apoptosis in patients with preeclampsia

目的:探讨抗血小板药物联合硫酸镁对子痫前期患者血小板功能及滋养细胞凋亡侵袭的影响。方法:选择在本院接受治疗的子痫前期患者68例作为研究对象,经随机数表法将入组患者分为对照组、研究组各34例。对照组患者接受硫酸镁解痉治疗,研究组患者接受小剂量阿司匹林联合硫酸镁治疗。对比两组患者治疗后血小板功能参数指标水平,胎盘组织中凋亡相关基因、侵袭相关基因表达量的差异。结果:治疗后,研究组血小板功能参数PLT水平高于对照组患者,MPV、PDW水平低于对照组;胎盘组织中促凋亡基因Caspase-3、p53、bax mRNA的表达量低于对照组,抗凋亡基因bcl-2mRNA的表达量高于对照组;胎盘组织中促侵袭基因MMP-2、MMP-9、CXCL16 mRNA的表达量高于对照组,抗侵袭基因RECK、DPPⅣmRNA的表达量低于对照组。结论:子痫前期患者接受小剂量阿司匹林联合硫酸镁治疗,可有效优化血小板功能,抑制胎盘滋养细胞凋亡并促进其侵袭功能。

Objective：To investigate the effects of antiplatelet drug combined with magnesium sulfate on platelet function and trophoblast apoptosis in patients with preeclampsia.Methods：A total of 68 patients with preeclampsia who were treated in this hospital between September 2016 and September 2017 were chosen as the research subjects and divided into the control group（n=34）and the study group（n=34）by the random number table method.Control group received magnesium sulfate sspasmolysis,and study group received low-dose aspirin combined with magnesium sulfate therapy.The differences in the levels of platelet function parameters as well as the expression levels of apoptosis-related genes and invasion-related genes in placental tissues were compared between the two groups of patients after treatment.Results：After treatment,the platelet function parameter PLT level in study group was higher than that in control group whereas MPV and PDW levels were lower than those in control group;pro-apoptosis genes Caspase-3,p53 and bax mRNA expression levels in placental tissues were lower than those of control group whereas anti-apoptosis gene bcl-2 mRNA expression level was higher than that of control group;pro-invasion genes MMP-2,MMP-9 and CXCL16 mRNA expression levels in placental tissues were higher than those of control group whereas anti-invasion genes RECK and DPPⅣ mRNA expression levels were lower than those of control group（P〈0.05）.Conclusion：Low-dose aspirin combined with magnesium sulfate treatment of patients with preeclampsia can effectively optimize the platelet function and inhibit the apoptosis of placental trophoblast cells and promote their invasion function.