高住低练与低住低练干预对肥胖儿童胰岛素敏感性、细胞因子分泌影响的差异

Different effects of living high-training low and living low-training low on insulin sensitivity and cytokine secretion in obese children

目的:探讨高住低练与低住低练干预对肥胖儿童胰岛素敏感性、细胞因子分泌影响的差异。方法:选择2015年9月～2018年2月间至本院就医的218例肥胖儿童,随机分为高住低练组、低住低练组各109例。高住低练组儿童接受高住低练干预、低住低练组儿童接受低住低练干预,均持续4周。对比干预前、干预4周后两组儿童血清中胰岛素敏感性相关指标水平及食欲相关激素、脂肪细胞因子含量的差异。结果:干预前,两组肥胖儿童血清中胰岛素敏感性相关指标水平以及食欲相关激素、脂肪细胞因子含量的差异不显著。干预4周后,高住低练组儿童血清中胰岛素敏感性相关指标ISI、FPIR、GDR的水平高于低住低练组;食欲相关激素CCK、PYY3-36的含量高于低住低练组,Ghrelin的含量低于低住低练组;脂肪细胞因子omentin-1、APN的含量高于低住低练组,chemerin、LEP的含量低于低住低练组。结论:肥胖儿童接受高住低练干预,较传统低住低练干预更能有效提升机体胰岛素敏感性并均衡食欲相关激素、脂肪细胞因子分泌。

Objective：To explore the different effects of living high-training low and living low-training low on insulin sensitivity and cytokine secretion in obese children.Methods：A total of 218 obese children who were treated in this hospital between September 2015 and February 2018 were selected and randomly divided into the living high-training low group（n=109）and living low-training low group（n=109）.Living high-training low group received living high-training low intervention,living low-training low group received living low-training low intervention,and the intervention of both groups lasted for 4 weeks.The differences in serum levels of insulin sensitivity-related indexes as well as the contents of appetite-related hormones and adipocytokines were compared between the two groups of children before intervention and after 4 weeks of intervention.Results：Before intervention,the levels of insulin sensitivity-related indexes as well as the contents of appetite-related hormones and adipocytokines in serum were not significantly different between two groups of obese children.After 4 weeks of intervention,serum insulin sensitivity-related indexes ISI,FPIR and GDR levels of living high-training low group were higher than those of living low-training low group;appetite-related hormones CCK and PYY3-36 contents were higher than those of living low-training low group whereas Ghrelin content was lower than that of living low-training low group;adipocytokines omentin-1 and APN contents were higher than those of living low-training low group whereas chemerin and LEP contents were lower than those of living low-training low group.Conclusion：Compared with traditional living low-training low intervention,living high-training low intervention is more effective in improving the insulin sensitivity and balance the secretion of appetite-related hormones and adipocytokines in obese children.