干扰素+炎琥宁治疗对手足口病患儿炎症反应及免疫应答的影响

Effect of interferon + Potassium Sodium Dehydroandrograpolide Succinate therapy on inflammatory response and immune response in children with hand-foot-mouth disease

目的:探讨干扰素+炎琥宁治疗对手足口病患儿炎症反应及免疫应答的影响。方法:选取2016年9月～2018年2月间在本院接受治疗的手足口病患儿116例作为研究对象,参照随机数表法分为对照组、炎琥宁组各58例。对照组患儿接受对症+干扰素治疗,炎琥宁患儿接受对症+干扰素+炎琥宁治疗,均持续1周。对比两组患儿治疗前后血清中炎症因子、黏附分子、体液免疫指标含量的差异。结果:治疗前,两组血清中炎症因子、黏附分子、体液免疫指标含量的差异不显著(P>0.05)。治疗1周后,炎琥宁组血清中炎症因子IL-1β、IL-10、PCT、hs-CRP的含量低于对照组;血清中黏附分子CD44、ICAM-1、VCAM-1的含量低于对照组;血清中体液免疫指标IgA、IgG、C3、C4的含量低于对照组(P<0.05)。结论:手足口病患儿接受干扰素+炎琥宁治疗,可有效减轻机体全身炎症反应并改善体液免疫功能。

Objective：To investigate the effect of interferon ＋ Potassium Sodium Dehydroandrograpolide Succinate therapy on inflammatory response and immune response in children with hand-foot-mouth disease.Methods：A total of 116 children with hand-foot-mouth disease who were treated in this hospital between September 2016 and February 2018 were selected as the study subjects and divided into the control group（n=58）and the Potassium Sodium Dehydroandrograpolide Succinate group（n=58）by random number table method.Control group received symptomatic＋interferon therapy,and Potassium Sodium Dehydroandrograpolide Succinate group received symptomatic ＋ interferon ＋ Potassium Sodium Dehydroandrograpolide Succinate therapy,and they were treated for 1 week.The differences in the serum contents of inflammatory factors,adhesion molecules and humoral immunity indexes were compared between the two groups before and after treatment.Results：Before treatment,serum levels of inflammatory factors,adhesion molecules and humoral immunity indexes were not significantly different between the two groups（P〈0.05）.After 1 week of treatment,serum inflammatory factors IL-1β,IL-10,PCT and hs-CRP levels of Potassium Sodium Dehydroandrograpolide Succinate group were lower than those of controlgroup;serum adhesion molecules CD44,ICAM-1 and VCAM-1 levels were lower than those of control group;serum humoral immunity indexes IgA,IgG,C3 and C4 levels were lower than those of control group（P〉0.05）.Conclusion：Interferon ＋Potassium Sodium Dehydroandrograpolide Succinate therapy can effectively reduce the systemic inflammatory response and improve the humoral immune function in children with hand-foot-mouth disease.