P2X7嘌呤能受体在自身免疫性疾病中的作用

Role of P2X7 purinergic receptors in autoimmune diseases

嘌呤能受体P2X配体门控离子通道7(P2X7R)是嘌呤能受体P2X家族的重要成员,分布于体内多种组织和器官,主要表达于单核细胞和巨噬细胞,在人体的固有免疫中发挥重要作用。多种炎症状态下炎症局部组织中P2X7R的表达上调,进而调控炎症介质的表达和释放,诱导细胞产生炎症细胞因子,介导炎症反应和免疫应答,参与自身免疫性疾病的发生和发展,近年来P2X7R的研究备受关注。本文主要对P2X7R在炎症反应中的作用及其在自身免疫性疾病中的研究进展做一综述。

Purinergic receptor P2 X ligand-gated ion channel 7（P2 X7 R）,an important member of the P2 X family of purinergic receptors,is up-regulated in a variety of inflammatory states,affecting the expression and release of inflammatory mediators,inducing cells to produce inflammatory cytokines and participating in inflammatory and immune responses. P2 X7 R plays an important role in the occurrence and development of autoimmune diseases. This review focuses on the role of P2 X7 R in inflammation and its progress in autoimmune diseases.