针刺辅助治疗肝硬化患者对症状改善及胃肠功能的影响

Effect of Acupuncture as Adjunct to the Treatment of Hepatic Cirrhosis Patients on the Improvement of Symptoms and Gastrointestinal Function

目的研究针刺辅助治疗肝硬化患者对症状改善及胃肠功能的影响。方法选取76例肝硬化患者,按照随机数字表法将患者分为对照组和观察组,每组38例。对照组采取内科常规的抗病毒以及保护肝细胞的药物等治疗,观察组在此基础上进行针刺辅助治疗。观察两组患者的治疗效果以及治疗前后血清HBV-DNA水平、血清肝纤维化指标等。结果两组治疗后肝功能的各项指标均比治疗前有所改善,且观察组优于对照组,差异具有统计学意义(P<0.05);观察组总有效率为92.1%,对照组总有效率为63.2%,观察组明显高于对照组(P<0.05)。治疗后两组血清HBV-DNA含量和肝纤维化指标均较治疗前改善,且观察组优于对照组,差异具有统计学意义(P<0.05)。与同组治疗前比较,对照组MOT呈现出上升趋势(P<0.05),GAS明显降低(P<0.05),D-乳酸水平有降低趋势(P<0.05);观察组血清MOT水平增加(P<0.05),GAS、D-乳酸水平下降(P<0.05);且观察组上述指标改善程度均明显优于对照组(P<0.05)。两组胃肠功能疗效相比较,观察组总有效率为81.6%,明显高于对照组(P<0.05)。结论针刺辅助治疗肝硬化患者能使患者的胃肠功能得到明显的改善,症状得到极大的缓解,患者的生活质量显著改善。

Objective To observe the effect of acupuncture as adjunct to the treatment of hepatic cirrhosis patients on the improvement of symptoms and gastrointestinal function. Method Seventy-six patients with hepatic cirrhosis were accrued and allocated to a control group and an observation group by the random number table, with 38 cases in each group. The control group received conventional medications for anti-virus and liver protection, while the observation group was additionally given acupuncture as adjunct treatment. The treatment effects in the two groups, and the HBV-DNA level in serum and serum indexes related to hepatic fibrosis before and after the intervention were observed. Result The two groups showed improvement in each parameter of liver function tests after the intervention, and the observation group was superior to the control group with statistical significance（P0.05）; the total effective rate was 92.1% in the observation group versus 63.2% in the control group, and the observation group was significantly higher than the control group（P0.05）. The two groups had improvements in serum content of HBV-DNA and indexes related to hepatic fibrosis after the treatment, and the observation group was superior to the control group with statistical significance（P0.05）. Intra-group comparison with the baseline values showed that the level of motilin（MOT） presented an increasing tendency（P0.05）, the level of gastrin（GAS） dropped significantly（P0.05）, and the level of D-lactate presented a decreasing tendency in the control group（P0.05）; the serum level of MOT increased（P0.05） and the levels of GAS and D-lactate dropped significantly in the observation group（P0.05）; the improvements in the above indexes in the observation group were more significant than those in the control group（P0.05）. In comparing the therapeutic efficacy for gastrointestinal function, the total effective rate was 81.6% in the observation group, significantly higher than that in the control group（P0.05）. Conclusion Acupuncture as an adjunct can significantly improve the gastrointestinal function and mitigate the symptoms in hepatic cirrhosis patients, and the quality of life can also be significantly improved.