维生素D对敬老院内老年人抑郁情绪的影响--1年随访研究

One year follow-up study on the effect of vitamin D supplementation on depressive mood in the aged living in nursing home

目的:探讨补充维生素D制剂对老年人抑郁情绪的影响。方法:236名在养老院生活的老年人随机分成两组,每组118名。两组在补充钙片(1 000 mg/d)的基础上,研究组服用维生素D制剂1 200 IU/d;对照组服用安慰剂;疗程1年。研究前后分别检测两组血清25-羟基维生素D[25(OH)D]水平,并应用流调中心抑郁自评量表(CES-D)评估两组老年人的抑郁情绪。结果:基线时两组血清25(OH)D水平及CES-D评分比较差异无统计学意义;补充钙剂和/或维生素D 1年后,两组血清25(OH)D水平显著高于基线时,且研究组显著高于对照组(P<0.05或P<0.001);研究组CES-D得分显著低于对照组(t=-3.57,P<0.001)。结论:常规补充维生素D制剂可有效纠正老年群体的血清维生素D水平,改善抑郁情绪。

Objective： To explore the effect of vitamin D supplementation on depressive mood in the aged living in nursing home. Method： Two hundreds and thirty-six aged people living in nursing homes were randomly divided into two groups,118 cases in each group. On the basis of calcium supplement（1 000 mg/d） for the two groups,the study group took 1 200 IU vitamin D/d,the control group received a placebo for one year.Before and after one year of the vitamin D supplement,the serum concentrations of 25（OH） D were measured and epidemiological studies-depression scale（CES-D） were assessed in the two groups. Results： At baseline,the two groups showed no significant difference on the serum 25（OH） D levels and the CES-D scores. After one year of calcium and/or vitamin D supplement,the study group demonstrated significantly higher serum 25（OH） D level and significantly lower score on the CES-D than baseline（t =-3. 57,P〈0. 001） and the control group（P〈0. 05 or P〈0. 001）. In the control group,the serum 25（OH） D level was significantly higher than that at the baseline; but CES-D score had no significant difference from that at the baseline. Conclusion：Regular use of vitamin D supplementation can effectively correct the serum vitamin D level and improve depressive mood in aged people living in the nursing homes.