阿司匹林联合氯吡格雷治疗急性大动脉粥样硬化性脑梗死患者的疗效分析

Aspirin Combined with Clopidogrel in the Treatment of Acute Atherosclerotic Cerebral Infarction

目的分析阿司匹林联合氯吡格雷治疗急性大动脉粥样硬化性脑梗死患者的疗效。方法该次研究对象方便选择该院在2015年12月—2018年1月接诊治疗的130例急性大动脉粥样硬化性脑梗死患者,通过随机数字表法将其平均分为65例参照组(实施阿司匹林治疗)与65例实验组(实施阿司匹林联合氯吡格雷治疗),比较两组患者不良反应发生率、治疗效果、NIHSS评分情况。结果实验组患者治疗总有效率为80.00%,参照组患者治疗总有效率为50.76%,组间差异有统计学意义(P<0.05);实验组不良反应发生率为7.69%、参照组患者不良反应为9.23%,组间差异无统计学意义(P>0.05);实验组治疗前NIHSS评分为(11.5±4.5)分,参照组患者治疗前NIHSS评分为(12.1±4.6)分,组间差异无统计学意义(P>0.05);实验组患者治疗后NIHSS评分为(5.8±2.4)分,参照组患者治疗后NIHSS评分为(9.4±1.8)分,组间差异有统计学意义(P<0.05)。结论阿司匹林联合氯吡格雷治疗急性大动脉粥样硬化性脑梗死患者,不仅可以改善患者临床病症,降低不良反应发生率,同时还可以提高治疗效果,安全可靠,因此,值得推广并使用。

Objective This paper tries to analyze the efficacy of aspirin combined with clopidogrel in the treatment of patients with acute large atherosclerotic cerebral infarction. Methods This study convenient selected 130 acute large atherosclerotic cerebral infarction patients admitted to this hospital from December 2015 to January 2018. They were equally divided into 65 cases in the reference group（using aspirin） by random number table method, and 65 cases in the experimental group（aspirin combined with clopidogrel treatment）, compared the incidence of adverse reactions, treatment effects,NIHSS scores. Results The total effective rate of treatment was 80.00% in the experimental group, and 50.76% in the reference group. The difference between the groups was significant（P〈0.05）, with statistical significance; the incidence of adverse reactions in the experimental group was 7.69%. The response rate was 9.23%. There was no significant difference between the two groups（P〉0.05）. There was no statistical significance. The NIHSS score was（11.5±4.5）points in the experimental group, and the NIHSS score was（12.1±4.6）points in the reference group. There was no significant difference between groups（P〉0.05）, there was no statistical significance; NIHSS score was（5.8±2.4）points after treatment in the experimental group, and the NIHSS score was（9.4±1.8）points after treatment in the reference group. There was a significant difference between groups（P〈0.05）. Conclusion Aspirin combined with clopidogrel in the treatment of patients with acute atherosclerotic cerebral infarction can not only improve the clinical symptoms of patients, reduce the incidence of adverse reactions,but also can improve the treatment effect, safe and reliable, it is worth to promote and use.