脂氧素及其异构体ATL的研究进展

Research Progress of Lipoxins and Its Isomer-ATL

脂氧素是一种有效的内源性反调节脂质介质,与15-立体异构体-阿司匹林诱生型脂氧素均在阻止炎症继续发展、促进痊愈、抗肿瘤及缓解炎症痛、神经痛和骨癌痛等病理性疼痛等方面发挥着有效的生物学作用。阿司匹林诱生型脂氧素与天然脂氧素有相似的生物学作用,但其性质更加稳定,因此,多被用于替代脂氧素来进行实验研究。对于脂氧素在炎症性疾病、病理性疼痛等方面的机制研究以及在肿瘤和癌症等多种疾病中的作用研究是近年来的研究热点。

Lipoxins（ LXs） is a class of effective endogenous deregulation lipid mediators,they and their 15-epimers（ aspirin triggered lipoxins,ATLs） play potent bioactions in preventing inflammation from continuing to develop,promoting healing,antitumor and relieving pathological pains such as inflammatory pain,neuralgia and bone cancer pain. ATLs have similar biological effects with natural LXs,but are much more stable than the nature LXs,therefore,ATLs are always used to replace LXs in studies. The research on the mechanism of LXs in inflammatory diseases and pathological pain,as well as its role in many diseases,such as tumor and cancer,is a research hotspot in recent years.