银屑病和其治疗相关的肿瘤患病风险

Malignancy Risk with Psoriasis and Its Treatment

银屑病是一种慢性炎症性自身免疫性皮肤病,可同时伴发多种疾病。随着传统治疗方法如甲氨蝶呤、环孢素、光疗以及肿瘤坏死因子抑制剂等生物制剂的应用,患者肿瘤的患病风险增加,其引起了研究者们的注意,其中皮肤鳞状细胞癌与某些治疗方法存在一定的关系,而淋巴瘤、黑素瘤等其他肿瘤与银屑病及其治疗方法间是否存在相关性还存在争议。同时,对于有肿瘤史的银屑病患者的治疗以及新型药物是否会影响肿瘤的发生还需进一步研究。

Psoriasis is a chronic inflammatory autoimmune skin disease,which may be accompanied with multiple diseases. Along with the traditional treatment methods,such as methotrexate,cyclosporin,phototherapy and the use of biological agents such as tumor necrosis factor inhibitors,the risks of tumor are increased which have attracted the attention of the researchers. There is a certain relationship between skin squamous cell carcinoma and some treatment methods,and the correlation between lymphoma,melanoma and psoriasis and its treatment remains controversial. At the same time,the treatment of psoriasis with a history of cancer and whether new drugs will affect the incidence of cancer still need further studies.