肺癌相关脑梗死的研究进展

Research Progress in Lung Cancer Related Cerebral Infarction

肺癌患者罹患脑梗死的风险明显高于正常人群,提示肺癌会直接或间接地导致脑梗死的发生,即发生肺癌相关脑梗死的可能。肺癌偶然被观察到会通过癌细胞侵犯左心房,引起心内血栓形成,导致脑梗死的发生;肺癌还会引起非细菌性血栓性心内膜炎,最终导致脑梗死的发生。然而,肺癌相关脑梗死以脑内多发性梗死灶、外周血D-二聚体、糖类抗原升高为临床特点,外周血糖类抗原升高不仅可能是肺癌相关脑梗死的血浆标志物,还可能与其发病机制有关,为肺癌相关脑梗死的防治提供了新的方向。

The incidence of cerebral infarction increases in patients with lung cancer,which indicates that lung cancer could direc-tly or indirectly cause cerebral infarction,regarded as lung cancer related cerebral infarction. Occasionally,lung cancer was found to induce ischemic cerebral infarction through cancer cell invading left atrium,causing thrombosis in the heart and cause the occurrence of cerebral infarction; lung cancer may also lead to nonbacterial thrombotic endocarditis,and finally inducing cerebral infarction. It has been found that lung cancer related cerebral infarction has the clinical feathers including multiple lesions in brain and elevated plasma D-dimer and carbohydrate antigen levels. And the elevated plasma carbohydrate antigen level is found associated to the pathogenesis of lung carbohydrate related cerebral infarction,which provides a new direction for the prevention and treatment.