软骨下骨在创伤性骨关节炎中的研究进展

Research Progress of Subchondral Bone in Post-Traumatic Osteoarthritis

创伤性骨关节炎是一种慢性进行性疾病,关节创伤后多种作用机制共同参与,最终导致关节软骨退化、骨赘形成以及功能障碍。其中,软骨下骨在骨关节炎的发生、发展中起着重要作用。在骨关节炎进程中,早期软骨下骨骨净吸收,晚期骨净形成,脱节的骨吸收和骨形成导致骨组织净体积增加。不论在健康还是病变的关节,软骨下骨与软骨表面的交流都存在。抗骨吸收药物抑制破骨细胞调控的软骨下骨重建是一项有潜力的早期干预骨关节炎的新方法。

Post-traumatic osteoarthritis is a chronic progressive disease in which various mechanisms are involved after joint trauma,eventually leading to articular cartilage degeneration,osteophyte formation and dysfunction. Among them,subchondral bone plays an important role in its occurrence and development. In the process of osteoarthritis,early net absorbance of subchondral bone followed by later net formation,an uncoupling of bone resorption and formation lead to a net increase in bone volume. In both the healthy and diseased joints,bone/cartilage crosstalk exists. Antiresorptives inhibition of osteoclast-mediated subchondral bone remodeling,is a promising new method for early intervention in osteoarthritis.