低分子肝素对重症肺炎患者体内细胞因子的影响

Effects of low molecular weight heparin on cytokines in patients with severe pneumonia

目的:探讨低分子肝素抑制重症肺炎患者炎性反应的机制。方法:收集重症肺炎患者共49例,随机分成两组,对照组给予常规治疗,观察组在常规治疗基础上加用低分子肝素5 000 U皮下注射,1次/d,连续治疗7 d。分别在治疗开始前与治疗后第7天,监测外周血中炎性细胞因子IL-6、IL-8、IL-10、IL-17、IL-23、TNF-α的变化。结果:与对照组相比,低分子肝素治疗组在治疗第7天,IL-6、IL-8、IL-10、IL-17、IL-23、TNF-α的水平明显降低(P<0.05),并且低分子肝素组机械通气时间明显降低。结论:低分子肝素可以通过抑制炎性细胞因子的生成,改善重症肺炎患者预后。

Objective： To explore the mechanism of low molecular weight heparin（ LMWH） to inhibit the inflammatory response of patients with severe pneumonia. Methods： Collected a total of 49 patients with severe pneumonia,randomly divided into two groups,control group given conventional treatment,observation group（ LMWH group） on the basis of conventional treatment combined with low molecular heparin sodium 5 000 U subcutaneous injection,1 time/day,for 7 days. The changes of the inflammatory cytokines IL-6,IL-8,IL-10,IL-17,IL-23 and TNF-α levels in the serum were monitored respectively before and after treatment. Results： Compared with control group,low molecular heparin treatment group in the treatment of 7 days,IL-6,IL-8,IL-10,IL-17,IL-23,TNF-α levels significantly decreased（ P 〈 0. 05）,and low heparin group mechanical ventilation time was obviously decreased too. Conclusion： Low molecular weight heparin can improve the prognosis of patients with severe pneumonia by inhibiting the levels of inflammatory cytokines.