养血清脑颗粒联合阿替普酶治疗急性脑梗死的疗效及对患者炎症因子和凝血功能的影响

Efficacy of Yangxue Qing Nao granule combined with alteplase in treating acute cerebral infarction and its effects on inflammatory factors and coagulation function

目的探讨养血清脑颗粒联合阿替普酶治疗急性脑梗死患者的疗效及对患者炎症因子和凝血功能的影响。方法选择2016年1月至2017年9月我院收治的急性脑梗死患者98例为研究对象,根据随机数字表法分为观察组和对照组,每组49例。对照组患者给予阿替普酶溶栓治疗,观察组患者在对照组治疗的基础上加用养血清脑颗粒治疗。比较两组患者的临床疗效;比较两组患者治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数评分、炎症因子水平和凝血功能的变化情况。结果观察组患者的治疗总有效率(91.84%)显著高于对照组(73.47%),临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的NIHSS评分均显著降低,观察组患者的NIHSS评分显著低于对照组,差异有统计学意义(P<0.05);两组患者Barthel指数评分均显著提高,观察组患者的Barthel指数评分显著高于对照组,差异有统计学意义(P<0.05);观察组患者的血清IL-1β、CRP、IL-6和TNF-α水平显著降低并且显著低于对照组(P<0.05);两组患者血清PT和APTT水平显著增高、Fib水平显著降低,观察组患者血清PT和APTT水平高于对照组、Fib水平低于对照组,差异有统计学意义(P<0.05)。结论养血清脑颗粒联合阿替普酶溶栓治疗急性脑梗死患者疗效显著,可有效减轻患者的炎症反应并改善凝血功能。

Objective To investigate the therapeutic efficacy of Yangxue Qing Nao granule combined with alteplase on acute cerebral infarction and its influence on inflammatory factors and coagulation function. Methods A total of 98 patients with acute cerebral infarction admitted to our hospital from January 2016 to September 2017 were selected as the subjects. According to the random table method, they were divided into observation group and control group, with 49 cases in each group. The control group was treated with thrombolytic therapy with alteplase, and the observation group was combined with Yangxue Qing Nao granule on the basis of the control group. The curative effect of the two groups was compared, and the changes of NIHSS score, Barthel index score, inflammatory factors and coagulation function were compared before and after treatment between the two groups. Results The total effective rate of the observation group （91.84%） was higher than that of the control group （73.47%）, with statistical significance （P〈0.05）. After treatment, the NIHSS score was decreased in both groups, and that in observation group was lower than control group, with statistical significance （P〈0.05）. The Barthel index score increased in both groups, and that in the observation group was higher than the control group （P〈0.05）. The serum IL-1β, CRP, IL-6 and TNF-α levels in the observation group were all decreased,which were lower than the control group （P〈0.05）. PT and APTT levels was increased and Fib was decreased in two groups,while PT and APTT levels in observation group were higher than that of control group, level of Fib was lower than that of control group,with statistical significance （P〈0.05）. Conclusion Yangxue Qing Nao Granules combined with alteplase proves obvious effects in the treatment of acute cerebral infarction by mitigating the inflammatory reaction and improving coagulation function.