幽门螺旋杆菌感染和年龄与血脂异常的临床相关性研究

The clinical research of the relation between helicobecter pylori infection and the age and lipid profile

目的研究幽门螺旋杆菌(helicobecter pylori,HP)感染和年龄与血脂异常的关系。方法用胶乳免疫比浊法检测1042例健康体检者血清幽门螺旋杆菌抗体(阳性用胶体金方法复检)同时用CHOD-PAP底物法检测患者血清总胆固醇(TC)、用GPO-PAP法检测甘油三酯(TG)、用直接法-过氧化氢酶清除法检测高密度脂蛋白(HDL)、用直接法-表面活性剂清除法检测低密度脂蛋白(LDL)水平,并分别以≤30岁,31-60岁,>60岁分三组进行观察各年龄段的感染阳性率及血脂的变化。结果随着年龄升高,HP感染率逐渐增高,>60岁组的HP感染率最高,且TC、TG和LDL均增高,HDL减低。结论幽门螺旋杆菌感染率随年龄增长而上升,并且血脂异常与HP感染相关。

Objective To investigate the relation between helicobecer pylori infection and age and aslipid profile. Methods We detected serum helicobacter pylori antibody by latex immune turbidimetric method in 1042 cases of healthy physical examination （re-examination by colloidal gold method）. At the same time we used CHOD-PAP substrate method to detect serum total cholesterol （TC） and used GPO-PAP method to detect triglyceride （TG） in patients. Meanwhile,we detected high-density lipoprotein （HDL） and low density lipoprotein （LDL） levels by hydrogen peroxide enzyme remove method and surfactant remove method, respectively. Finally,we classified all samples into 3 groups （!30,31-60,and 〉60） according to their age,and observed the positive infection rate and the change of blood lipid. Results With increasing age,Hp infection rate increased gradually. The 〉60 years old group has the highest infection rate. Meanwhile, they has higher TC, TG,LDL and lower HDL. Conclusion Helicobacter pylori infection rate increased with age, and dyslipidemia was associated with HP infection.