水性聚氨酯/硫酸化壳聚糖复合膜的制备及其血液相容性

Synthesis and Hemocompatibility of WPU/SCS Composite Membrane

采用己二异氰酸酯(HDI)三聚体合成了水性聚氨酯(WPU),采用浸渍法将WPU与硫酸化壳聚糖(SCS)通过接枝反应制备出WPU/SCS复合膜.通过红外光谱、热重分析、差示扫描量热法对复合膜进行了表征,并采用动态凝实验研究了复合膜的血液相容性.结果表明:WPU与SCS发生了共价结合;复合膜的玻璃化转变温度为53.2℃,热分解温度为300~400℃;WPU/SCS复合膜的血液相容性优于水性聚氨酯.因此WPU/SCS复合膜是具有潜力的生物医用材料.

The waterborne polyurethane（WPU） was synthesized by using trimers of 1,6-hexamethylene diisocyanate（HDI）. WPU film was dipped in solution of sulfated chitosan（SCS） to prepare WPU/SCS composite films. The obtained films were characterized by FT-IR,TGA and DSC. The hemocompatibility of the composite membrane was studied by dynamic coagulation test. The results showed that the WPU was combined with SCS through covalent bonds,that the composite membrane had a Tgof 53.2 ℃ and a thermal decomposed temperature of 300-400 ℃,and that the composite membrane had better hemocompatibility than WPU. WPU/SCS composite membrane is a potential biomedical material.