三七总皂苷联合胺碘酮对阵发性房颤左心房内径和心锚重复蛋白的影响

Effect of panax notoginsenosides plus amiodarone on left atrial diameter and cardiac ankyrin repeat protein in patients with paroxysmal atrial fibrillation

[目的]探讨三七总皂苷(PNS)联用胺碘酮对阵发性房颤(PAF)患者左心房内径(LAD)和心锚重复蛋白(CARP)的影响。[方法]将70例PAF患者随机分为治疗组35例(PNS联用胺碘酮)与对照组35例(单用胺碘酮)。随访6个月,观察复发情况、测定治疗前及治疗6个月后LAD及CARP水平。[结果]在治疗6个月后,治疗组窦性心律维持率显著高于对照组(P<0.05);治疗组LAD明显低于对照组(P<0.05);治疗组CARP水平明显低于对照组(P<0.05)。[结论]PNS联用胺碘酮较单用胺碘酮可明显减少房颤复发,降低PAF患者LAD和CARP水平。

[Objective] To discuss the effect of panax notoginsenosides （PNS） or plus amiodarone on left atrial diameter （LAD） and cardiac ankyrin repeat protein （CARP） in patients with paroxysmal atrial fibrillation （PAF）. [Methods] Seventy PAF patients were randomized into PNS plus amiodarone group （35 cases） and amiodarone group （35 cases）. The rate of sinus rhythm maintenance, LAD and CARP were obsezwed within 6 months of follow up. [Results] It＇s demonstrated that the rate of sinus rhythm maintenance in PNS plus amiodarone group was significantly higher than that in amiodarone group （P〈0.05）. LAD in PNS plus amiodarone group was significantly lower than that in amiodarone group （P〈0.05）. CRAP in PNS plus amiodarone group was significantly lower than that in amiodarone group （P〈0.05）. [Conclusion] Compared to amiodarone alone, PNS plus amiodarone can significantly reduce AF recurrence, LAD and CARP in PAF patients.