20例阿尔茨海默病患者海马代谢磁共振波谱检测探讨

Discussion of metabolic magnetic resonance spectroscopy in hippocampus in 20 patients with Alzheimer's disease

目的 :探究阿尔茨海默病患者海马代谢的磁共振波谱的分布规律以及特点,为临床诊断提供重要的参考依据。方法 :采用对比实验方法,以20例阿尔茨海默病患者作为实验组患者,选取同期年龄性别等基本相似的20例健康人作为对照组,对两组研究对象的智力状况、认知能力等进行简单的评定,同时采用核磁共振波普成像检查技术和方法对两组研究对象的核磁波谱分布状况和规律进行对比和分析。结果 :两组智力状况、认知能力、海马区核磁共振谱的各项指标存在显著差异(P<0.05)。结论 :阿尔茨海默病患者海马区的图谱明显与健康研究对象有明显的差别,这临床诊断提供了有效的证据,具有重要的价值和意义。

Objective： To explore the distribution and characteristics of magnetic resonance spectrum（MRS） of hippocampal metabolism in the patients with Alzheimer＇s disease, and provide the important reference basis for the clinical diagnosis. Methods： A simple assessment of the intelligence and cognitive abilities in both of the experimental group（20 cases） and the control group（20 cases） was performed by a comparative experimental method. Meanwhile the distribution and regularity of MRS were compared and analyzed between the two groups by MRI. Results： There exited significant differences between the two groups in intelligence status, cognitive ability and hippocampal MRS（P〈0.05）. Conclusion： The atlas of the hippocampus in the patients with Alzheimer＇s disease are obviously different from those of the healthy subjects, which can provide effective evidence for clinical diagnosis and is of great value and significance.