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PTTG、VEGF-C、VEGFR-3在宫颈鳞癌中的表达及与淋巴管生成的关系分析

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摘要 目的:分析PTTG、VEGF-C、VEGFR-3在宫颈鳞癌中的表达及与淋巴管生成的关系.方法:选取本院2016年6月~2017年6月期间诊治的50例宫颈鳞癌患者作为研究对象,设为研究组,另选取同时间段在本院行子宫切除并经病理证实的50例宫颈慢性炎患者作为对照研究对象,设为对照组,运用免疫组织化学法检测两组患者宫颈组织标本的PTTG、VEGF-C、VEGFR-3表达,利用D2-40标记的微淋巴管计算微淋巴管密度.结果:研究组PTTG的阴性率为30.0%,阳性率为70.0%;对照组PTTG均呈阴性表达,阴性率为100.0%;两组对比差异显著(P〈0.05).研究组VEGF-C的阴性率为2.0%,阳性率为98.0%;对照组VEGF-C的阴性率为76.0%,阳性率为24.0%;两组对比差异显著(P〈0.05).研究组VEGF-C的阴性率为2.0%,阳性率为98.0%;对照组VEGF-C的阴性率为74.0%,阳性率为26.0%;两组对比差异显著(P〈0.05).PTTG、VEGF-C、VEGFR-3的表达与微淋巴管密度均有显著的正相关性(P〈0.05).结论:PTTG、VEGF-C、VEGFR-3均可在宫颈鳞癌中表达,且与淋巴管生成呈正相关性.
出处 《医学食疗与健康》 2018年第4期23-23,25,共2页 Medical Diet and Health
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