低分子肝素钠治疗D-二聚体升高复发性流产的观察

Observation of Low Molecular Heparin Sodium in Treatment of Recurrent Abortion with Elevated D-dimer

目的：分析低分子肝素钠治疗D-二聚体升高复发性流产的临床疗效.方法：选择我院2013年1月-2013年12月妇科收治的130例D-二具体升高复发性流产患者,根据随机数字表法将患者分为观察组和对照组两组,每组65例,对照组给予传统方法治疗,肌射hCG和黄体酮直至妊娠84d,观察组在与对照组相同治疗的基础上联合低分子肝素钠治疗,患者计划怀孕的前30d开始脐周注射低分子肝素钠4000U治疗,直至妊娠16周,比较两组患者的保胎成功率,观察流产者的平均妊娠时间,记录两组治疗期间不良反应发生率.结果：观察组保胎成功率84.61%（55例）,明显高于对照组29.23%（19例）,差异有统计学意义（P〈0.05）;观察组流产流者平均妊娠时间显著长于对照组,差异有统计学意义（P〈0.05）;两组间不良反应发生率比较,差异无统计学意义,（P〉0.05）.结论：D-二聚体升高复发性流产者采用低分子肝素钠治疗,治疗效果显著优于传统疗法,可以显著提高保胎成功率,无任何不良反应.

Objective：To analyze the clinical effect of low molecular Heparin sodium in treatment of D-dimer elevated recurrent abortion.Methods：130 cases of D-2 specific elevated recurrent abortion were treated in our hospital from January 2013 to December 2013.The patients were divided into observation group and control group according to random number table method,65 cases in each group,the control group was treated with traditional method,muscle hCG and progesterone up to 8D,and the control group was treated with the same basis of Heparin combination of low molecule The patient planned to start the first 30D of pregnancy around the umbilical cord with low molecular Heparin sodium 4,000 U treatment until 16 weeks of gestation,compared the success rate of the two groups,observed the average gestation time of the miscarriage,and recorded the incidence of adverse reactions during treatment in both groups.Results The success rate was 84.61%（55 cases）,which was significantly higher than 29.23%（19 cases）in the control group.The difference was statistically significant（P〈0.05）The mean gestation time of the abortion group was significantly longer than that of the control group（P〈0.05）;There was no significant difference in the incidence of adverse reactions between the two groups.No statistically significant difference（P〉0.05）.Conclusion The treatment of low molecular Heparin sodium in patients with recurrent abortion with elevated D-dimer is superior to traditional treatment,and can significantly improve the success rate of preserving the fetus.