右美托咪定用于神经阻滞的研究进展

Research progress of dexmedetomidine in nerve block

右美托咪定(Dex)是一种高选择性的α2肾上腺素能受体激动剂,目前作为局麻药的辅助用药在神经阻滞中取得了良好的临床效果,可缩短局麻药的起效时间、延长镇痛时效并减少术后镇痛药的使用,同其他局麻药辅助药物相比,右美托咪定可提供更优的镇痛效果和时程,以及较少的不良反应。

Dexmedetomidine（Dex）is a specific alpha-2-adrenergic agonist which was widely used in nerve blocks as an adjuvant to local anesthetic（LA）in order to shortening the onset time,prolonging the analgesic effect and reducing the postoperative analgesic consumption.When compared with other adjuvant to LA,Dex was effective in providing better analgesia efficacy with fewer side effects.