摘要
在催化量的三氯化铝存在时,二乙酸碘苯可以在温和条件下将奥美拉唑硫醚(2)氧化成奥美拉唑。与已报道方法相比,该法具有反应条件温和,后处理简单,收率高的优点,有较好的应用前景。
Ph I（ OAc）2 was found to be an effective oxidant for the synthesis of omeprazole from omeprazole sulfide（2） under mild condition,in the presence of catalytic AlCl3. This methodology has several advantages compared with traditional methodologies,including milder reaction condition,easier workup and higher yield,and is suitable for industrial production.
作者
马金焕
臧营
Ma Jinhuan;Zang Ying(Lunan Pharmaceutical Group,National Engineering and Technology Research Center of Chirality Pharmaceutical,Linyi 276006,China)
出处
《山东化工》
CAS
2018年第13期32-32,34,共2页
Shandong Chemical Industry
关键词
三氯化铝
二乙酸碘苯
奥美拉唑硫醚
奥美拉唑
aluminium chloride
（diacetoxyiodo） benzene
omeprazole sulfide
omeprazole
