摘要
以间氟苯胺与乙氧基亚甲基丙二酸二乙酯为原料,经过缩合、高温环合、水解、高温脱羧、氯化,合成7-氟-4-氯-喹啉,7-氟-4-氯-喹啉与不同苯胺反应生成4个喹啉类化合物(J_1~J_4),其结构经过~1H NMR和MS确认.采用MTT法对目标化合物进行体外肿瘤细胞增殖抑制活性评价,结果显示目标化合物具有抑制肿瘤细胞增殖活性.
Using m-fluoroanline and ethoxym ethylene oxalic acid ester as starting material,7-fluoro-4-chloro-quinoline was synthesized through cyclization,high temperature cyclization,hydrolysis,high temperature decarboxylation,chlorination. Four quinoline compounds( J1- J4) were synthesized by 7-fluoro-4-chloro-quinoline and different anilines,and their structures were confirmed by -1H NMR and MS. The antiproliferative activity of the compounds against three kinds of cancer cells( SGC7901,HT1080,A549) was evaluated by MTT,and the results showthat the target compounds exhibited inhibitory activity of the three kinds of cancer cells.
作者
刘丹
袁莹
李雪
刘智鑫
LIU Dan;YUAN Ying;LI Xue;LIU Zhi-xin(Shenyang University of Chemical Technology,Shenyang 110142,China)
出处
《沈阳化工大学学报》
CAS
2018年第2期149-152,共4页
Journal of Shenyang University of Chemical Technology
基金
辽宁省教育厅资助项目(L2013171)
辽宁省自然科学基金资助项目(2015020695)