木丹颗粒在糖尿病周围神经病变气虚血瘀证中的应用

Application of mudan granules in treatment of patients with diabetic peripheral neuropathy differentiated as type of qi deficiency and blood stasis

目的分析木丹颗粒在糖尿病周围神经病变气虚血瘀证中的应用效果。方法将60例糖尿病周围神经病变气虚血瘀证患者随机分为2组,对照组行西医治疗,观察组在西医治疗基础上加木丹颗粒治疗,比较2组疗效。结果治疗后,观察组中医症候积分显著低于对照组(P<0.05),左腓总神经、右腓总神经、左胫神经、右胫神经传导速度均显著高于对照组(P<0.05)。2组治疗后空腹血糖、餐后2 h血糖、糖化血红蛋白水平均显著低于治疗前(P<0.05)。结论在糖尿病周围神经病变气虚血瘀证中治疗中应用木丹颗粒,可有效减轻患者症状,改善神经传导速度,降低血糖水平。

Objective To analyze the effect of mudan granules on the treatment of patients with diabetic peripheral neuropathy differentiated as type of qi deficiency and blood stasis. Methods Totally 60 patients with diabetic peripheral neuropathy differentiated as type of qi deficiency and blood stasis were randomly divided into two groups. Control group was treated with routine western medicine, while observation group was treated with mudan granules on the basis of control group. Curative effect was compared. Results After treatment, score of TCM syndrome in observation group was significantly lower than the control group （ P 〈0.05）, and left sural nerve, phil always right tibial nerve, left or right tibial nerve conduction velocity were significantly higher than control group （ P 〈 0.05）. In both groups, fasting blood glucose, postprandial 2 h blood glucose and glycosylated hemoglobin level after treatment were significantly lower than those before treatment （ P 〈0.05）. Conclusion Mudan granules can effectively relieve symptoms, improve nerve conduction velocity and reduce blood sugar level in patients with diabetic peripheral neuropathy differentiated as type of qi deficiency and blood stasis.