Lp-PLA2、LDL-C与急性脑梗死改良TOAST分型之间的关系

Relationship between Lp-PLA2,LDL-C and Modified TOAST Classification of Acute Cerebral Infarction

目的探讨不同TOAST分型及NIHSS评分的急性脑梗死患者血浆脂蛋白相关磷脂酶A2(Lp-PLA2)和低密度脂蛋白胆固醇(LDL-C)的水平差异。方法选取我院收治的发病72h内的300例急性脑梗死患者作为研究对象,同时选取100例健康体检者作为正常对照组,对比各TOAST分型及NIHSS评分组血浆Lp-PLA2、LDL-C含量与正常对照组之间的差异。结果 LAA组和SAO组急性脑梗死患者的血浆Lp-PLA2及LDL-C水平明显高于其他亚型组和对照组,且LAA组明显高于SAO组;中重型卒中组患者血浆Lp-PLA2及LDL-C水平明显高于轻型卒中组患者。以上差异均有统计学意义(P均<0.05)。结论血浆Lp-PLA2和LDL-C水平在不同病因及严重程度的急性脑梗死患者中存在差异,有可能为急性脑梗死的诊断提供新依据和参考指标。

Objective To investigate the difference of plasma lipoprotein associated phospholipase A2（ Lp-PLA2） and low density lipoprotein cholesterol（ LDL-C） levels between different TOAST classification and NIHSS score in patients with acute cerebral infarction. Methods 300 patients with acute cerebral infarction in our hospital were selected as the research objects,and 100 healthy people were selected as the normal control group at the same time.The differences of plasma Lp-PLA2 and LDL-C levels between the TOAST classification and NIHSS score groups were compared with those of the normal control group.Results The levels of plasma LpPLA2 and LDL-C in patients with acute cerebral infarction in group LAA were the highest,followed by group SAO and both other subtypes and the control group; The levels of plasma Lp-PLA2 and LDL-C in patients with moderate to severe stroke were significantly higher than those of patients with mild stroke.The above differences were statistically significant（ P〈 0. 05）. Conclusion Plasma levels of Lp-PLA2 and LDL-C are different in patients with acute cerebral infarction between different etiology and severity,which may provide a new basis and reference index for the diagnosis of acute cerebral infarction.