血小板参数在判断慢性丙型肝炎RNA水平中的价值

The value of platelet parameters in determining the level of chronic hepatitis C RNA

以78例丙肝抗体阳性患者为研究对象,分析血小板计数(PLT),血小板分布宽度(PDW),平均血小板体积(MPV),血小板压积(PCT)及丙肝RNA载量。HCV-RNA阳性组PLT和PCT减低,PDW和MPV增高(P<0.001);RNA阳性组中低HCV-RNA载量组有更高的PLT和PCT,更低的PDW和MPV(P<0.05);HCV-RNA的高低和各参数间相关性分析显示HCV-RNA载量和MPV呈正相关性(r=0.306,P=0.026),和PLT(r=0.493,P<0.001),PCT(r=0.444,P=0.001)呈负相关性,和PDW相关性分析无统计学意义(r=0.258,P=0.063)。血小板参数能辅助判断丙肝病毒复制的严重程度。

The blood platelet count（ PLT）,platelet distribution width（ PDW）,mean platelet volume（ MPV）,platelet volume（ PCT） and hepatitis C RNA load were analyzed in 78 cases of hepatitis C antibody positive patients.Compared with HCV-RNA negative group,HCV-RNA positive group of PLT and PCT decreased significantly,PDW and MPV were significantly increased（ P〈0. 001）; low HCV-RNA load group had higher PLT,PCT and lower PDW,MPV（ P〈0. 05）; HCV-RNA load was positively correlated with MPV（ r = 0. 306,P = 0. 026）,and negatively correlated with PLT（ r = 0. 493,P = 0. 000） and PCT（ r = 0. 444,P = 0. 001）,the correlation analysis between PDW and HCV-RNA was not statistically significant（ r = 0. 258,P = 0. 063）. Monitoring platelet parameters in patients with hepatitis c can help determine the severity of virus replication.