纳洛酮与纳美芬治疗急性酒精中毒的效果对比

Comparison of naloxone and nalmefene in treatment of acute alcoholism

目的对比分析纳洛酮与纳美芬治疗急性酒精中毒的效果。方法以88例急性酒精中毒患者为研究对象,随机分为A组(给予盐酸纳洛酮治疗)和C组(给予盐酸纳美芬治疗),各44例。对比两组治疗后的临床疗效、意识恢复以及肝功能情况。结果治疗后,C组总有效率(95.45%)显著高于A组(54.55%)(P<0.05),清醒时间和临床症状恢复时间均短于A组(P<0.05);两组治疗后CK、ALT及AST值无显著差异(P>0.05)。结论对于急性酒精中毒患者,应用纳美芬治疗,相对纳洛酮而言,可显著提高临床疗效,缩短症状缓解时间,可作为治疗的首选药物。

Objective To compare the effects of naloxone and nalmefene in the treatment of acute alcoholism. Methods A total of 88 patients with acute alcoholism were randomly divided into group A（naloxone hydrochloride was administered） and group C（nalmefene hydrochloride was administered）（n=44, respectively）. The clinical efficacy, consciousness recovery and liver function after the treatment were compared between the two groups. Results After the treatment, the total effective rate of group C（95.45%） was significantly higher than that in group A（54.55%）（P〈0.05）; the awakening time and clinical symptoms recovery time were shorter than those of group A（P〈0.05）, and there was no significant difference in CK, ALT and AST between the two groups（P〈0.05）.Conclusion For the patients with acute alcoholism, nalmefene can significantly improve the clinical efficacy and shorten the time of symptomatic relief in comparison with naloxone, so it can be used as the first choice for the treatment.