糖皮质激素在儿童难治性肺炎支原体肺炎治疗中的应用效果分析

Analysis of the Application Effect of Glucocorticoids in the Treatment of Children with Refractory Pneumonia and Mycoplasma Pneumonia

目的:探讨糖皮质激素在儿童难治性肺炎支原体肺炎治疗中的应用效果。方法:收集2016年2月至2018年2月入院的200例难治性肺炎支原体肺炎患儿随机分为两组,对照组患儿给予常规治疗方案,糖皮质激素组患儿则加用糖皮质激素,比较两组患儿住院相关指标、肺功、炎性指标、免疫指标、影像学检查异常结果与不良反应。结果:糖皮质激素组患儿退热时间、总发热时间、痉咳缓解时间、总痉咳时间、抗生素使用时间与病情反复次数均显著性低于对照组;治疗后FVC、FEV1、PEF、FEF25、FEF75、IgG、CD3+/CD4+与CD3+/CD8+水平组间比较均显著性高于对照组,WBC与CRP水平均显著性低于对照组;总体影像学检查异常结果显著性优于对照组,差异具有统计学意义(P<0.05);两组患儿治疗期间药物不良反应率不存在统计学意义(P>0.05)。结论:糖皮质激素在儿童难治性肺炎支原体肺炎治疗中的应用效果显著,安全性高,具有借鉴意义。

Objective： To investigate the effect of glucocorticoids in the treatment of children with refractory pneumonia and mycoplasma pneumonia. Methods： 200 children with refractory pneumonia and mycoplasma pneumonia admitted from February 2016 to February 2018 were randomly divided into two groups. The control group was given routine treatment. The glucocorticoid group was given glucocorticoids. Hormones,hospital-related indicators,lung function,inflammatory markers,immune parameters,imaging findings,and adverse reactions were compared between the two groups. Results： The time of fever,total fever,cough remission,total cough time,antibiotic use time,and number of relapses were significantly lower in the glucocorticoid group than in the control group; FVC,FEV1,PEF,and FEF25 after treatment.,FEF75,IgG,CD3＋/CD4＋ and CD3＋/CD8＋ levels were significantly higher than the control group,WBC and CRP levels were significantly lower than the control group; overall imaging examination results were significantly better than the control group,the difference has Statistical significance（P 0.05）; There was no statistically significant difference in drug adverse reaction rate between the two groups of children（P 0.05）. Conclusion： The application of glucocorticoids in the treatment of children with refractory pneumonia caused by mycoplasma pneumonia is effective,with high safety and useful for reference.