二甲双胍联合达英-35治疗育龄期妇女多囊卵巢综合征的疗效观察

Observation of the Effect of Metformin combined with Dimethyl-35 in the treatment of Polycystic Ovary Syndrome in Women of Childbearing Age

目的:探讨二甲双胍联合达英-35治疗育龄期妇女多囊卵巢综合征的疗效。方法:收集2015年1月至2017年6月入院的育龄期妇女多囊卵巢综合征患者70例,随机分为两组,单药组患者给予二甲双胍,联合组患者则加用达英-35,比较两组患者疾病相关参数,包括BMI、WHR、平均卵泡体积、平均窦卵泡数目、内膜厚度、FPG、FINS、Homa-IR、LH、FSH、LH/FSH、T、TC、TG、HDL-C、LDL-C,总体治疗效果、BBT双相率、妊娠结局与安全性。结果:联合组患者BMI(23.40±0.82)、平均卵泡体积(7.01±0.50)、平均窦卵泡数目(5.05±0.73)、FINS(17.38±2.75)、Homa-IR(2.96±0.50)、LH(4.70±0.73)、LH/FSH(0.71±0.19)与TG水平(115.56±25.18)组间比较均显著性低于单药组(24.47±0.80,7.94±0.58,6.35±0.90,19.41±2.60,3.76±0.61,6.09±1.03,1.09±0.20,130.44±23.78),内膜厚度(9.70±1.09)、FSH(12.36±2.48)与HDL-C水平(72.48±9.31)均显著性高于单药组(7.07±0.86,10.05±1.76,59.96±9.05),存在显著性差异(P<0.01);总有效率(94.29%)、BBT双相率(62.86%)、排卵(88.57%)与妊娠率(77.14%)均明显单药组(74.29%,34.29%,68.57%,51.43%),存在明显差异(P<0.05);两组患者药物不良反应率(17.14%vs.5.71%)不存在明显差异(P>0.05)。结论:二甲双胍联合达英-35治疗育龄期妇女多囊卵巢综合征的疗效显著,安全性较高,具有借鉴意义。

Objective： To investigate the curative effect of metformin combined with da-35 on polycystic ovary syndrome in women of childbearing age. Methods： 70 women of childbearing age who were admitted to hospital from January 2015 to June 2017 were randomly divided into two groups： metformin in the single drug group and up to Ying-35 in the combined group Disease-related parameters in two groups of patients,overall treatment effect,BBT biphasic rate,pregnancy outcome and safety. Results： BMI（23.40 ± 0.82）,average follicular volume（7.01 ± 0.50）,mean antral follicle count（5.05 ± 0.73）,FINS（17.38 ± 2.75）,Homa-IR（2.96 ± 0.50）,LH ± 0.73）,LH/FSH（0.71 ± 0.19） and TG（115.56 ± 25.18） were significantly lower than those in the single drug group（24.47 ± 0.80,7.94 ± 0.58,6.35 ± 0.90,19.41 ± 2.60,3.76 ± 0.61,6.09± 1.03,1.09 ± 0.20,130.44 ± 23.78）,intima thickness（9.70 ± 1.09）,FSH（12.36 ± 2.48） and HDL-C（72.48 ± 9.31） were significantly higher than those in the single drug group（7.07（94.29%）,bipolar rate of BBT（62.86%）,ovulation（88.57%） and pregnancy rate（77.14%） were significantly different between the two groups） Were significantly higher in single drug group（74. 29%,34. 29%,68. 57%,51. 43%）,there was a significant difference（P 0.05）. There was no significant difference between the two groups in the adverse drug reaction rate（17.14% vs. 5.71%）（P 0.05）. Conclusion： Metformin combined with dimethyl-35 is effective and safe in the treatment of polycystic ovary syndrome in women of childbearing age.