摘要
获得性免疫缺陷综合征(AIDS)在普通人群中的发病率逐渐增加,随着高效抗逆转录病毒治疗(HAART)的应用,AIDS患者的病死率逐渐降低,但骨质疏松脆性骨折的发生率显著高于健康人群。本综述主要介绍AIDS患者骨质疏松脆性骨折的发生率和危险因素等,人类免疫缺陷病毒(HIV)和HAART对成骨细胞、破骨细胞OPG/RANK/RANKL系统的作用机制和不良反应;简述AIDS患者骨质疏松脆性骨折药物预防和治疗方法。
The incidence of acquired immune deficiency syndrome（AIDS） in general population increased gradually, but the mortality of patients with AIDS decreased gradually with the application of highly effective antiretroviral therapy, and the incidence of fragility fracture in patients with AIDS is significantly higher than that of normal population. This paper introduces the occurrence of fragility fracture of AIDS, the effect of human immunodeficiency virus（HIV） and highly active antiretroviral therapy（HAART） on osteoblasts and osteoclasts OPG/RANK/RANKL system. Prevention and treatment of drugs to AIDS patients with fragility fracture was also introduced.
作者
王帅
赵汝岗
张强
Wang Shuai;Zhao Rugang;Zhang Qiang(Orthopedic Department,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2018年第3期221-224,共4页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
基金
感染病科国家临床重点专项建设项目
关键词
获得性免疫缺陷综合征
骨质疏松
脆性骨折
机制
药物
Acquired immune defciency syndrome
Osteoporosis
Fragility fracture
Mechanism
Drug
