胃癌患者应用CA724、CEA、CA199肿瘤标志物联合检验的应用分析

Application of joint test of CA724,CEA and CA199 in patients with gastric cancer

目的探讨胃癌患者采用CA724、CEA、CA199肿瘤标志物联合检验的价值。方法 53例胃癌患者(研究组)和同期53例其他胃部疾病患者(对照组),均采用肿瘤标志物CA724、CEA、CA199联合检测,并结合患者的病理检测结果进行分析。结果研究组CA724、CEA、CA199水平均高于对照组;胃癌Ⅲ、Ⅳ期患者CA724、CEA、CA199水平均高于Ⅰ、Ⅱ期患者(P<0.05)。CA724、CEA、CA199单项检测胃癌的特异度较高,但是准确率和灵敏度较低,联合检测的准确率和灵敏度均显著高于单独检测(P<0.05)。结论胃癌患者采用CA724、CEA、CA199肿瘤标志物联合检测的准确率和灵敏度较高,可以有效的提高临床诊断效果,具有较高的临床推广价值。

Objective To evaluate the value of CA724,CEA and CA199 in gastric cancer patients.Methods Fifty-three gastric cancer patients（ study group） and 53 patients with other stomach diseases（ control group） were simultaneously measured serum CA724,CEA and CA199 and analyzed with patient＇s pathological test results. Results The levels of CA724,CEA and CA199 in the study group were significantly higher than those in the control group（ P〈0. 05）.The levels of CA724,CEA and CA199 in gastric cancer patients with stage Ⅲ and Ⅳ were significantly higher than those in stage Ⅰ and Ⅱ（ P〈0. 05）.CA724,CEA and CA199 had higher specificity,but the accuracy and sensitivity were lower.The accuracy and sensitivity of combined detection were significantly higher than those of single test（ P〈0. 05）.Conclusion The accurate and sensitivity of the joint test in gastric cancer patients are high. This can effectively improve the clinical diagnosis with a high clinical value.