小剂量地塞米松在新生儿胎粪吸入性肺炎中的应用价值探讨

Exploration on application value of low dose dexamethasone in the treatment of newborn with meconium aspiration pneumonia

目的评价新生儿胎粪吸入性肺炎中小剂量地塞米松的应用价值。方法选取80例胎粪吸入性肺炎新生儿,按照随机数字表法随机分为治疗组与对照组各40例,治疗组在对照组常规综合治疗基础上加用小剂量地塞米松,比较两组患儿的治疗效果及相关指标。结果两组患儿治疗前血清IL-6、IL-8及肿瘤坏死因子-α(TNF-α)水平比较无明显差异(P>0.05),治疗后治疗组较治疗前及同期对照组比较均有明显改善(P<0.05);治疗组各项主要症状、体征改善时间均明显短于对照组(P<0.05)。结论新生儿胎粪吸入性肺炎治疗中加用小剂量地塞米松可显著减轻机体炎症反应,改善症状及体征,缩短病程,对提高临床疗效,改善患儿预后有一定价值。

Objective： To evaluate the application value of low dose dexamethasone in the treatment of newborn with meconium aspiration pneumonia. Methods： 80 cases of meconium aspiration pneumonia of newborn were selected,they were randomly divided into treatment group and control group with 40 cases in each group,the treatment group were used conventional treatment combined with small dose of dexamethasone on the basis of the treatment for the control group,the treatment effect and the related index of the two groups were compared. Results： The serum IL-6,IL-8 and tumor necrosis factor alpha（ TNF-α） had no significant difference level（ P〉0. 05） between the patients of the two groups before treatment,after treatment the treatment group were improved more significantly（ P〈0. 05） than that before treatment and the control group at the same period; Each of the main symptom and physical sign improving time of the treatment group were significantly shorter than that of the control group（ P〈0. 05）. Conclusion： Adding low-dose dexamethasone in neonatal meconium aspiration pneumonia treatment can significantly reduce the inflammatory reaction,improve the symptoms and signs,shorten the course of disease,it has certain value to improve the clinical efficacy and improve the prognosis of sick children.