碳酸锂与阿立哌唑治疗双相障碍抑郁疗效分析

Clinical Efficacy and Safety of Lithium Carbonate Combined With Aripiprazole in Treatment of Bipolar Depression

目的观察碳酸锂联合阿立哌唑治疗双相障碍抑郁发作的临床效果,探讨临床用药的有效性与安全性。方法随机将我院2016年7月—2017年7月收治的70例双相障碍抑郁发作患者分为两组,每组35例。对照组行碳酸锂治疗,观察组在对照组的基础上行阿立哌唑治疗。两组均持续治疗2个月。比较两组HAMD评分、YMRS评分等指标。结果治疗后,观察组HAMD评分、YMRS评分及治疗有效率等均优于对照组(P<0.05)。两组不良反应情况差异不具有统计学意义(P>0.05)。结论碳酸锂联合阿立哌唑治疗双相障碍抑郁发作疗效理想,有利于迅速改善病情,不良反应少,安全可靠。

Objective To observe the clinical effect of lithium carbonate combined with aripiprazole in the treatment of bipolar disorder with depressive episode, and to explore the effectiveness and safety of clinical medication. Methods 70 patients with bipolar disorder who were treated in our hospital from July 2016 to July 2017 were randomly divided into two groups, 35 cases in each group. The control group used lithium carbonateand the observation group used aripiprazole on the basis of the control group. The two groups were treated with continuous treatment for two months. The HAMD score and YMRS score were compared between the two groups. Results After treatment, the HAMD score, YMRS score and effective rate of observation group were significantly better than those of the control group（P〈0.05）. There was no significant difference in adverse reaction between the two groups（P〉0.05）. Conclusion Lithium carbonate combined with aripiprazole is effective in the treatment of bipolar depressive episode, which is beneficial to the rapid improvement of the condition, less adverse reactions, safe and reliable.