β痕迹蛋白对冠脉介入诊疗术后造影剂肾病预测价值的相关性

Correlation study of the Predictive Value of Beta-trace Protein to Contrast-induced Nephropathy after Coronary Intervention

目的探讨血/尿β痕迹蛋白(βTP)浓度预测造影剂肾病的相关性.方法收集昆明市第一人民医院收内科2016年9月至2016年12月行冠脉介入诊断和\或治疗的88例患者,发生CIN患者为CIN组(7例);未发生CIN患者为非CIN组(81例),共88例.采用ELISA法测定血/尿β痕迹蛋白浓度进行用SPSS进行统计分析.结果研究结果示,CIN组及非CIN组术前、术后2 h、术后24 h血βTP水平差异有统计学意义(P<0.05);CIN组及非CIN组术前、术后2 h、术后24 h尿βTP水平差异有统计学意义(P<0.05);血βTP 2 h术后的ROC曲线下面积(AUC)为0.761,诊断界值为567.568,敏感度和特异度分别为71.4%和81.5%;尿βTP 2 h术后的ROC曲线下面积(AUC)为0.967,诊断界值为1 428.893时,敏感度和特异度分别为100%和97.5%.结论血/尿βTP术后2 h浓度可以作为预测造影剂肾病的新指标,其中尿βTP敏感度及特异度优于血βTP,且尿液样本较血液样本更容易收集.

Objective To investigate the correlation of the concentration of blood/urine beta-trace protein（βTP） in the prediction of contrast-induced nephropathy. Methods This study enrolled 88 patients with interventional diagnosis or treatment from september to December 2016 in the first hospital of Kunming and the patients were divided into two groups： CIN group（nn = 7） and non-CIN group（n = 81）. The concentration of blood/urine βTP was measured by ELISA method and the results was analysed with SPSS.Re s ults There was significant difference in the level of blood βTP before the operation,2 h after operation and 24 h after the operation between the two groups（P〈0.05）,so was that in the level of urine βTP（P〈0.05）. The area under ROC curve（AUC） of blood βTP 2 h after the operation was 0.761,the diagnostic value was 567.568,and the sensitivity and specificity were 71.4% and 81.5% while the area of ROC curve（AUC） of urine βTP 2 h after the operation was0.967,the diagnostic value was 1428.893,and the sensitivity and specificity were 100% and 97.5%.Conclus ion The concentration of blood/urine βTP 2 h after the operation can be used as a new indicator to predict contrast-induced nephropathy. The sensitivity and specificity of urine βTP is better than those of blood βTP,and urine samples are easier to be collected than blood samples.