奥沙利铂联合替吉奥方案与XELOX方案在晚期结直肠癌治疗中的副作用对比

Comparison of side effects between Oxaliplatin combined with S-1 and XELOX regimen in the treatment of advanced colorectal cancer

目的探讨奥沙利铂联合替吉奥方案与XELOX方案在晚期结直肠癌治疗中的副作用。方法 80例晚期结肠癌患者,随机分为试验组和对照组,每组40例。对照组患者采取XELOX方案治疗,试验组患者采用奥沙利铂联合替吉奥方案治疗,比较两组患者的副作用发生情况。结果两组患者骨髓抑制、胃肠道反应、口腔黏膜病变发生率比较差异无统计学意义(P>0.05);试验组手足综合征和肝损伤发生率分别为20.0%、15.0%,均高于对照组的5.0%、2.5%,差异有统计学意义(P<0.05)。结论对直肠癌晚期患者使用XELOX方案其副作用明显低于奥沙利铂联合替吉奥方案,值得在临床推广。

Objective To investigate the side effects of Oxaliplatin combined with S-1 and XELOX regimen in the treatment of advanced colorectal cancer. Methods 80 patients with advanced colorectal cancer were randomly divided into the experimental group and the control group, 40 cases in each group. The control group wa given XELOX regimen for treatment, the experimental group was given Oxaliplatin combined with S-1 regimen, the side effects of the two groups were compared. Results There were no statistically significant differences in the incidence of bone marrow inhibition, gastrointestinal reactions and oral mucosal lesions（P0.05）. The incidence of hand foot syndrome and liver injury in the experimental group were 20.0%, 15.0% respectively, which were significantly higher than 5.0% and 2.5% in the control group, the differences were statistically significant（P〈0.05）. Conclusion For patients with advanced rectal cancer, the side effects of XELOX regimen are significantly lower than those of Oxaliplatin combined with S-1 regimen, it is worthy of clinical promotion.