中药成分肠吸收模型研究进展与思考

Intestinal Absorption Model of Component of Chinese Medicinal:Its Research Progress and Reflection

中药具有化学成分复杂,分析难度大等特点,如何从方法和技术上解决中药复杂体系中有效成分群筛选的研究难题,是近几年来国内外探索的热点。中药肠吸收谱与药物谱、药效谱结合可以快速、简便地筛选、优化中药材有效成分群。目前,肠吸收多用于研究中药单体、单味中药和中药复方的有效吸收成分及其相互作用规律。因此,本文介绍了近几年国内外有关中药成分肠吸收的模型,对各种方法的适用性特点进行了总结,并对其不足之处进行了探讨,为中药有效成分群筛选的相关研究提供参考,并为中药新药的发现和临床上中药的合理使用提供借鉴。

Chinese medicinal has the characteristic of complex chemical composition and it is difficult to analyze. Active constituents screening in the complex system of TCM from the aspects of methods and technologies has become a hot topic in recent years. The combination of intestinal absorption spectrum,medicine spectrum,and pharmacodynamics spectrum can quickly and easily select and optimize the active ingredients of Chinese medicinal. At present,intestinal absorption is mainly used to study monomer,single Chinese medicinal,and TCM compound formula. This article described domestic and foreign models of intestinal absorption of TCM ingredients in recent years,it summarized the applicability of various methods,and discussed their shortcomings; which provided reference for relative study of the screening of active constituents of Chinese materia medica. It also provided reference for the discovery of new Chinese medicinal and the rational use of it.