静脉滴注盐酸氨溴索佐治小儿支气管肺炎顽固性痰鸣音的疗效分析

CLINICAL EFFECTS OF INTRAVENOUS DRIP OF AMBROXOL HYDROCHLORIDE ON OBSTINATE PHLEGM SOUND IN CHILDREN WITH BRONCHOPNEUMONIA

目的:分析静脉滴注盐酸氨溴索佐治小儿支气管肺炎顽固性痰鸣音的临床疗效。方法:134例支气管肺炎患儿随机分为研究组和对照组,每组67例。对照组患儿给予常规治疗,研究组在此基础上静脉滴注盐酸氨溴索。检测两组患儿治疗前、后血清白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)的水平,并观察临床治疗效果。结果:治疗后,研究组和对照组患儿血清IL-6、hs-CRP水平均明显低于治疗前(P<0.05);并且,研究组患儿治疗后血清IL-6、hs-CRP水平明显低于对照组治疗后,组间比较差异具有统计学意义(P<0.05)。研究组治疗总有效率为95.52%(64/67),明显高于对照组(83.58%,56/67,P<0.05)。结论:静脉滴注盐酸氨溴索可有效消除肺部顽固性痰鸣音,提高小儿支气管肺炎的临床疗效,值得临床推广应用。

Objective： To analyze the clinical effects of intravenous drip of ambroxol hydrochloride on obstinate phlegm sound in children with bronchopneumonia. Methods： 134 children with bronchopneumonia were randomly divided into study group and control group with 67 children in each group. The children in control group were given conventional therapy; on this basis, the children in study group were also given intravenous drip of ambroxol hydrochloride. The serum interleukin-6（IL-6） and hypersensitive C reactive protein（hs-CRP） level before and after treatment were respectively detected. And the clinical effects of 2 groups were also observed. Results： After treatment the serum IL-6 and hs-CRP level of children in 2 groups were all obviously decreased（P〈0.05）; moreover, the serum IL-6 and hs-CRP level of children in study group after treatment were significantly lower than control group after treatment（P〈0.05）. The total effective rate of study group was 95.52%（64/67）, which was obviously higher than control group（P〈0.05）. Conclusions： Intravenous drip of ambroxol hydrochloride can eliminate the obstinate phlegm sound in lung effectively, and also can improve the clinical effects of children＇s bronchopneumonia, so it is worthy of application in clinic.